PMID- 11796203
OWN - NLM
STAT- MEDLINE
DCOM- 20020327
LR  - 20190826
IS  - 0891-5849 (Print)
IS  - 0891-5849 (Linking)
VI  - 32
IP  - 2
DP  - 2002 Jan 15
TI  - Plasma lipophilic antioxidants and malondialdehyde in congestive heart failure 
      patients: relationship to disease severity.
PG  - 148-52
AB  - Plasma levels of malondialdehyde (MDA), vitamin A, and of antioxidant 
      micronutrients including vitamin E, lutein, zeaxanthin, beta-cryptoxanthin, 
      lycopene, and alpha- and beta-carotene were measured in 30 patients with class II 
      and III congestive heart failure (CHF) according to the New York Heart 
      Association (NYHA) classification and in 55 controls. Ejection fraction was 
      evaluated by echocardiography in all patients as a measure of the emptying 
      capacity of the heart. Plasma levels of all measured compounds were significantly 
      lower and MDA significantly higher in patients compared to controls (p <.001). 
      Class II NYHA patients showed significantly lower MDA levels and significantly 
      higher levels of vitamin A, vitamin E, lutein, and lycopene than class III 
      patients. Ejection fraction was inversely correlated with MDA levels and directly 
      correlated with vitamin A, vitamin E, lutein, and lycopene levels in patients. 
      The present study supports the concept that an increased consumption of 
      vitamin-rich fruits and vegetables might help in achieving cardiovascular health.
FAU - Polidori, Maria Cristina
AU  - Polidori MC
AD  - Institute of Physiological Chemistry I, Heinrich-Heine University, Dusseldorf, 
      Germany. polidori@uni-duesseldorf.de
FAU - Savino, Ketty
AU  - Savino K
FAU - Alunni, Gianfranco
AU  - Alunni G
FAU - Freddio, Michela
AU  - Freddio M
FAU - Senin, Umberto
AU  - Senin U
FAU - Sies, Helmut
AU  - Sies H
FAU - Stahl, Wilhelm
AU  - Stahl W
FAU - Mecocci, Patrizia
AU  - Mecocci P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Free Radic Biol Med
JT  - Free radical biology & medicine
JID - 8709159
RN  - 0 (Xanthophylls)
RN  - 0 (Zeaxanthins)
RN  - 01YAE03M7J (beta Carotene)
RN  - 11103-57-4 (Vitamin A)
RN  - 1406-18-4 (Vitamin E)
RN  - 36-88-4 (Carotenoids)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - X72A60C9MT (Lutein)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Carotenoids/*blood
MH  - Echocardiography
MH  - Female
MH  - Heart Failure/*blood
MH  - Humans
MH  - Lipid Peroxidation/physiology
MH  - Lutein/blood
MH  - Male
MH  - Malondialdehyde/*blood
MH  - Middle Aged
MH  - *Severity of Illness Index
MH  - Stroke Volume/physiology
MH  - Vitamin A/*blood
MH  - Vitamin E/*blood
MH  - Xanthophylls
MH  - Zeaxanthins
MH  - beta Carotene/analogs & derivatives/blood
EDAT- 2002/02/14 10:00
MHDA- 2002/03/28 10:01
CRDT- 2002/02/14 10:00
PHST- 2002/02/14 10:00 [pubmed]
PHST- 2002/03/28 10:01 [medline]
PHST- 2002/02/14 10:00 [entrez]
AID - S0891584901007821 [pii]
AID - 10.1016/s0891-5849(01)00782-1 [doi]
PST - ppublish
SO  - Free Radic Biol Med. 2002 Jan 15;32(2):148-52. doi: 
      10.1016/s0891-5849(01)00782-1.