PMID- 11796619
OWN - NLM
STAT- MEDLINE
DCOM- 20020221
LR  - 20210526
IS  - 0019-9567 (Print)
IS  - 1098-5522 (Electronic)
IS  - 0019-9567 (Linking)
VI  - 70
IP  - 2
DP  - 2002 Feb
TI  - Chemokine and chemokine receptor dynamics during genital chlamydial infection.
PG  - 844-50
AB  - Current design strategies for vaccines against certain microbial pathogens, 
      including Chlamydia trachomatis, require the induction and targeting of specific 
      immune effectors to the local sites of infection known as the mucosal effector 
      sites. Chemokines and their receptors are important mediators of leukocyte 
      trafficking and of the controlled recruitment of specific leukocyte clonotypes 
      during host defense against infections and during inflammation. We analyzed the 
      dynamics of chemokine and chemokine receptor expression in genital mucosae during 
      genital chlamydial infection in a murine model to determine how these molecular 
      entities influence the development of immunity and the clearance of infection. A 
      time course study revealed an increase of up to threefold in the levels of 
      expression of RANTES, monocyte chemotactic protein 1 (MCP-1), 
      gamma-interferon-inducible protein 10 (IP-10), macrophage inflammatory protein 
      1alpha (MIP-1alpha), and intercellular adhesion molecule type 1 (ICAM-1) after 
      genital infection with the C. trachomatis agent of mouse pneumonitis. Peak levels 
      of expression of RANTES, MCP-1, and MIP-1alpha occurred by day 7 after primary 
      infection, while those of IP-10 and ICAM-1 peaked by day 21. Expression levels of 
      these molecules decreased by day 42 after primary infection, by which time all 
      animals had resolved the infection, suggesting an infection-driven regulation of 
      expression. A rapid upregulation of expression of these molecules was observed 
      after secondary infection. The presence of cells bearing the chemokine receptors 
      CCR5 and CXCR3, known to be preferentially expressed on Th1 and dendritic cells, 
      was also synchronous with the kinetics of immune induction in the genital tract 
      and clearance of infection. Results demonstrated that genital chlamydial 
      infection is associated with a significant induction of chemokines and chemokine 
      receptors that are involved in the recruitment of Th1 cells into the site of 
      infection. Future studies will focus on how selective modulation of chemokines 
      and their receptors can be used to optimize long-term immunity against CHLAMYDIA:
FAU - Belay, Tesfaye
AU  - Belay T
AD  - Department of Microbiology, Biochemistry and Immunology, Morehouse School of 
      Medicine, Atlanta, Georgia 30310, USA.
FAU - Eko, Francis O
AU  - Eko FO
FAU - Ananaba, Godwin A
AU  - Ananaba GA
FAU - Bowers, Samera
AU  - Bowers S
FAU - Moore, Terri
AU  - Moore T
FAU - Lyn, Deborah
AU  - Lyn D
FAU - Igietseme, Joseph U
AU  - Igietseme JU
LA  - eng
GR  - AI41231/AI/NIAID NIH HHS/United States
GR  - G12 RR003034/RR/NCRR NIH HHS/United States
GR  - GM08247/GM/NIGMS NIH HHS/United States
GR  - S06 GM008248/GM/NIGMS NIH HHS/United States
GR  - R01 AI041231/AI/NIAID NIH HHS/United States
GR  - S06 GM008247/GM/NIGMS NIH HHS/United States
GR  - RR03034/RR/NCRR NIH HHS/United States
GR  - GM08248/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Infect Immun
JT  - Infection and immunity
JID - 0246127
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL3)
RN  - 0 (Chemokine CCL4)
RN  - 0 (Chemokine CCL5)
RN  - 0 (Chemokine CXCL10)
RN  - 0 (Chemokines)
RN  - 0 (Chemokines, CXC)
RN  - 0 (Cxcr3 protein, mouse)
RN  - 0 (Macrophage Inflammatory Proteins)
RN  - 0 (Receptors, CCR5)
RN  - 0 (Receptors, CXCR3)
RN  - 0 (Receptors, Chemokine)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
SB  - IM
MH  - Animals
MH  - Chemokine CCL2/genetics
MH  - Chemokine CCL3
MH  - Chemokine CCL4
MH  - Chemokine CCL5/genetics
MH  - Chemokine CXCL10
MH  - Chemokines/*genetics
MH  - Chemokines, CXC/genetics
MH  - Chlamydia Infections/*immunology
MH  - Chlamydia trachomatis/*immunology
MH  - Disease Models, Animal
MH  - Female
MH  - *Gene Expression
MH  - Gene Expression Profiling
MH  - Genital Diseases, Female/*immunology
MH  - Intercellular Adhesion Molecule-1/genetics
MH  - Kinetics
MH  - Macrophage Inflammatory Proteins/genetics
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Receptors, CCR5/*genetics
MH  - Receptors, CXCR3
MH  - Receptors, Chemokine/*genetics
PMC - PMC127682
EDAT- 2002/01/18 10:00
MHDA- 2002/02/22 10:01
PMCR- 2002/02/01
CRDT- 2002/01/18 10:00
PHST- 2002/01/18 10:00 [pubmed]
PHST- 2002/02/22 10:01 [medline]
PHST- 2002/01/18 10:00 [entrez]
PHST- 2002/02/01 00:00 [pmc-release]
AID - 0869 [pii]
AID - 10.1128/IAI.70.2.844-850.2002 [doi]
PST - ppublish
SO  - Infect Immun. 2002 Feb;70(2):844-50. doi: 10.1128/IAI.70.2.844-850.2002.