PMID- 11797172
OWN - NLM
STAT- MEDLINE
DCOM- 20020306
LR  - 20051122
IS  - 1537-6591 (Electronic)
IS  - 1058-4838 (Linking)
VI  - 34
IP  - 4
DP  - 2002 Feb 15
TI  - Influenza encephalopathy associated with infection with human herpesvirus 6 
      and/or human herpesvirus 7.
PG  - 461-6
AB  - Influenza-associated encephalopathy is often reported in young Japanese children, 
      but its pathogenesis is unknown. Although influenza virus can be demonstrated by 
      throat culture for patients with encephalopathy, cultures of samples of 
      cerebrospinal fluids (CSF) do not yield the virus. Eight patients with 
      encephalopathy or complicated febrile convulsions had influenza virus infection 
      diagnosed by means of culture, polymerase chain reaction (PCR), or rapid 
      diagnosis using throat swabs. In all 8 cases, the results of PCR testing of CSF 
      specimens for influenza virus were negative. On the other hand, human herpesvirus 
      6 (HHV-6) DNA was demonstrated in CSF specimens obtained from 2 of 8 patients. In 
      3 of 8 patients, the presence of human herpesvirus 7 (HHV-7) DNA was demonstrated 
      in CSF specimens. Some cases of influenza-associated encephalopathy reported in 
      Japan may be attributable to a dual infection with influenza virus and HHV-6, -7, 
      or both. Another possibility is that latent HHV-6 or HHV-7 in the brain is 
      reactivated by influenza, causing encephalopathy or febrile convulsions.
FAU - Sugaya, Norio
AU  - Sugaya N
AD  - Department of Pediatrics, Nippon Kokan Hospital, Kawasaki, Kanagawa 210-0852, 
      Japan. sugaya-n@za2.so-net.ne.jp
FAU - Yoshikawa, Tetsushi
AU  - Yoshikawa T
FAU - Miura, Masaru
AU  - Miura M
FAU - Ishizuka, Takehiro
AU  - Ishizuka T
FAU - Kawakami, Chiharu
AU  - Kawakami C
FAU - Asano, Yoshizo
AU  - Asano Y
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20020104
PL  - United States
TA  - Clin Infect Dis
JT  - Clinical infectious diseases : an official publication of the Infectious Diseases 
      Society of America
JID - 9203213
SB  - IM
MH  - Child, Preschool
MH  - *Herpesvirus 6, Human/isolation & purification
MH  - *Herpesvirus 7, Human/isolation & purification
MH  - Humans
MH  - Infant
MH  - Influenza, Human/*complications
MH  - Male
MH  - Polymerase Chain Reaction
MH  - Roseolovirus Infections/*complications
MH  - Seizures, Febrile/*complications
EDAT- 2002/01/18 10:00
MHDA- 2002/03/07 10:01
CRDT- 2002/01/18 10:00
PHST- 2001/05/22 00:00 [received]
PHST- 2001/09/10 00:00 [revised]
PHST- 2002/01/18 10:00 [pubmed]
PHST- 2002/03/07 10:01 [medline]
PHST- 2002/01/18 10:00 [entrez]
AID - CID010709 [pii]
AID - 10.1086/338468 [doi]
PST - ppublish
SO  - Clin Infect Dis. 2002 Feb 15;34(4):461-6. doi: 10.1086/338468. Epub 2002 Jan 4.