PMID- 11797838
OWN - NLM
STAT- MEDLINE
DCOM- 20020131
LR  - 20051116
IS  - 0731-8898 (Print)
IS  - 0731-8898 (Linking)
VI  - 20
IP  - 4
DP  - 2001
TI  - Fluorescence in situ hybridization (FISH) in genetic toxicology.
PG  - 293-8
AB  - Structural and numerical chromosomal aberrations have been considered important 
      biological end points in genotoxic studies. Conventional solid staining (such as 
      Giemsa) has been employed to evaluate the frequencies ofinduced chromosomal 
      aberrations following exposure to chemical or physical agents. Recently, 
      molecular cytogenetic techniques that have become available, such as fluorescence 
      in situ hybridization (FISH) using chromosome-specific or chromosomal 
      regions-specific DNA libraries, have increased the resolution of detection of 
      aberrations. The present paper reviews briefly the results obtained from basic 
      and applied studies using the FISH technique.
FAU - Natarajan, A T
AU  - Natarajan AT
AD  - Department of Radiation Genetics and Chemical Mutagenesis, Leiden University 
      Medical Center, The Netherlands.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Environ Pathol Toxicol Oncol
JT  - Journal of environmental pathology, toxicology and oncology : official organ of 
      the International Society for Environmental Toxicology and Cancer
JID - 8501420
SB  - IM
MH  - *Chromosome Aberrations
MH  - *DNA Damage
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence/methods
MH  - Mutagenicity Tests
MH  - Neoplasms/etiology/genetics
RF  - 26
EDAT- 2002/01/19 10:00
MHDA- 2002/02/01 10:01
CRDT- 2002/01/19 10:00
PHST- 2002/01/19 10:00 [pubmed]
PHST- 2002/02/01 10:01 [medline]
PHST- 2002/01/19 10:00 [entrez]
PST - ppublish
SO  - J Environ Pathol Toxicol Oncol. 2001;20(4):293-8.