PMID- 11798051
OWN - NLM
STAT- MEDLINE
DCOM- 20020618
LR  - 20190513
IS  - 1369-3786 (Print)
IS  - 1369-3786 (Linking)
VI  - 39
IP  - 6
DP  - 2001 Dec
TI  - IgE antibody response to the main antigenic component of Paracoccidioides 
      brasiliensis in patients with paracoccidioidomycosis.
PG  - 475-8
AB  - Paracoccidioidomycosis (PCM) has two main clinical presentations, a chronic form 
      (CF) and an acute, more severe form (AF). The AF is associated with a more marked 
      dysfunction of the patient's immune response, and a distinct 
      anti-Paracoccidioides brasiliensis immunoglobulin (Ig)A and IgG antibody subclass 
      expression, compared with that seen in the CF. In this study we investigated the 
      presence of IgE antibodies against the main P. brasiliensis antigen (a 43-kDa 
      molecule) in the serum of PCM patients using an enzyme-linked immunosorbent 
      assay. We found that 100% of the AF patients (n = 16) produced IgE antibodies, 
      mostly at high levels, whereas only 9 (27%) out of 33 CF patients produced this 
      isotype. Interestingly, these nine patients presented higher serological titers 
      on the counter-immunoelectrophoresis assay than did those who did not produce 
      IgE; a finding that suggests that they had a relatively more severe disease. As 
      IgE is a characteristic feature of the AF patients, and switching to a positive 
      IgE response is dependent on interleukin-4, our results support the notion that 
      the relatively more severe impairment of cellular immunity in the AF is probably 
      related to a Th-2 pattern of immune response.
FAU - Biselli, P J
AU  - Biselli PJ
AD  - Laboratorio de Alergia e Imunologia Clinica e Experimental, Faculdade de Medicina 
      do Universidade de Sao Paulo, Sao Paulo, Brazil.
FAU - Juvenale, M
AU  - Juvenale M
FAU - Mendes-Giannini, M J
AU  - Mendes-Giannini MJ
FAU - Duarte, A J
AU  - Duarte AJ
FAU - Benardi, G
AU  - Benardi G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Med Mycol
JT  - Medical mycology
JID - 9815835
RN  - 0 (43 kDa protein, Paracoccidioides)
RN  - 0 (Antibodies, Fungal)
RN  - 0 (Antigens, Fungal)
RN  - 0 (Fungal Proteins)
RN  - 0 (Glycoproteins)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Oligosaccharides)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Antibodies, Fungal/*blood
MH  - Antigens, Fungal/*immunology
MH  - *Fungal Proteins
MH  - Glycoproteins/*immunology
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Immunoglobulin G/classification
MH  - Oligosaccharides/*immunology
MH  - Paracoccidioides/*immunology
MH  - Paracoccidioidomycosis/*immunology
EDAT- 2002/01/19 10:00
MHDA- 2002/06/19 10:01
CRDT- 2002/01/19 10:00
PHST- 2002/01/19 10:00 [pubmed]
PHST- 2002/06/19 10:01 [medline]
PHST- 2002/01/19 10:00 [entrez]
AID - 10.1080/mmy.39.6.475.478 [doi]
PST - ppublish
SO  - Med Mycol. 2001 Dec;39(6):475-8. doi: 10.1080/mmy.39.6.475.478.