PMID- 11798675
OWN - NLM
STAT- MEDLINE
DCOM- 20060124
LR  - 20221207
IS  - 0578-1426 (Print)
IS  - 0578-1426 (Linking)
VI  - 38
IP  - 6
DP  - 1999 Jun
TI  - [Study on the association between tumor necrosis factor alpha gene polymorphism 
      and systemic lupus erythematosus].
PG  - 393-6
AB  - OBJECTIVE: To examine whether polymorphism within the tumor necrosis factor alpha 
      (TNFalpha) gene is associated with the susceptibility and clinic manifestations 
      to systemic lupus erythematosus (SLE) in the patients of Han ethnic group 
      collected from the Northern China. METHODS: TNF(1) and TNF(2) subtypes of 
      TNFalpha gene were defined by polymerase chain reaction-single strand 
      conformation polymorphism (PCR-SSCP) analysis in 89 Chinese patients with SLE and 
      70 ethnically matched controls from Peking Union Medical College Hospital. All 
      SLE patients were diagnosed by the American Rheumatological Association SLE 
      diagnostic criteria setup in 1982. Human leukocyte antigen (HLA)-DR(2) gene 
      frequency was assigned by PCR with sequence-specific primers (SSP-PCR). RESULTS: 
      The frequencies of TNF(2) and HLA-DR(2) were significantly increased in SLE 
      patients respectively compared to that of the controls (0.23 vs 0.14, RR = 1.85, 
      P < 0.05; 0.36 vs 0.22, RR = 2.02, P < 0.01). Both TNF(2) and HLA-DR(2) were 
      associated with SLE independently (RR = 3.96, P < 0.05; RR = 3.07, P < 0.05), but 
      there was no association between the two genes. In TNF(2) positive patients, the 
      positive rate of anti-SSA antibody was apparently higher and the incidence of 
      lupus nephritis was significantly increased. CONCLUSION: Both TNF(2) and 
      HLA-DR(2) gene may play a role in SLE susceptibility. Anti-SSA antibody and lupus 
      nephritis were strongly associated with TNF(2) gene.
FAU - Wang, M
AU  - Wang M
AD  - Department of Clinical Immunology, Peking Union Medical College Hospital, Beijing 
      100730.
FAU - Dong, Y
AU  - Dong Y
FAU - Huang, S
AU  - Huang S
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Nei Ke Za Zhi
JT  - Zhonghua nei ke za zhi
JID - 16210490R
RN  - 0 (HLA-DR2 Antigen)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Asian People
MH  - China
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - HLA-DR2 Antigen/*genetics
MH  - Humans
MH  - Lupus Erythematosus, Systemic/*genetics
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Single-Stranded Conformational
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 2002/01/19 10:00
MHDA- 2006/01/25 09:00
CRDT- 2002/01/19 10:00
PHST- 2002/01/19 10:00 [pubmed]
PHST- 2006/01/25 09:00 [medline]
PHST- 2002/01/19 10:00 [entrez]
PST - ppublish
SO  - Zhonghua Nei Ke Za Zhi. 1999 Jun;38(6):393-6.