PMID- 11798697
OWN - NLM
STAT- MEDLINE
DCOM- 20041007
LR  - 20140226
IS  - 0578-1426 (Print)
IS  - 0578-1426 (Linking)
VI  - 38
IP  - 9
DP  - 1999 Sep
TI  - [Dynamic changes of neurotrophic factors in different cerebral areas after full 
      cerebral ischemia and reperfusion in old rats].
PG  - 619-21
AB  - OBJECTIVE: To explore the relationship between vascular dementia and nerve growth 
      factor (NGF) and brain-derived neurotrophic factor (BDNF). METHODS: 42 male and 
      female senile Wistar rats were randomized into control and experimental groups. 
      The control group was subdivided into A, and C three groups and the experimental 
      group into 6 subgroups, i.e 15 min of ischemia alone and ischemia combined with 
      reperfusion of 1 h, 6 h, 2 d, 4 d and 9 d. Swimming maze was performed before and 
      after operation. The contents of NGF and BDNF in different parts of brain were 
      examined in different periods of ischemia and reperfusion with ABC method of 
      immunocytochemistry. RESULTS: NGF expression in frontal lobes reached a peak 
      level in 2 days after reperfusion and then disappeared quickly, that in parietal 
      lobes showed a moderate level in 15 minutes of ischemia and reached a peak in 9 
      days of reperfusion. However, there is no expression in thalamus in early 
      ischemia and reperfusion, but reexpression occurred after 2 days of reperfusion. 
      BDNF expression showed a peak level after 2 days of reperfusion and then 
      decreased in frontal lobes, but a high level of expression that was unchanged in 
      parietal lobes and hippocampal areas. The increasing expression in thalamus 
      occurred only 9 days after reperfusion. CONCLUSION: The distribution of BDNF was 
      wider than that of NGF. There was a good protective action of NGF and BDNF in 
      frontal lobes in the early period of ischemia with reperfusion and there existed 
      persistent and prompt action of the neurotrophic factors in parietal lobes and 
      hippocampal areas. The protective action of NGF in thalamus was poor, but that of 
      BDNF was good.
FAU - Li, A
AU  - Li A
AD  - Department of Neurology, The Second Teaching Hospital of Norman Bethune 
      University of Medical Sciences, Changchun 130041.
FAU - Yao, J
AU  - Yao J
FAU - Song, C
AU  - Song C
FAU - Wang, Y
AU  - Wang Y
FAU - Wang, S
AU  - Wang S
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Nei Ke Za Zhi
JT  - Zhonghua nei ke za zhi
JID - 16210490R
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Animals
MH  - Brain/metabolism
MH  - Brain Ischemia/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Female
MH  - Male
MH  - Nerve Growth Factor/*metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Reperfusion Injury/*metabolism
EDAT- 2002/01/19 10:00
MHDA- 2004/10/08 09:00
CRDT- 2002/01/19 10:00
PHST- 2002/01/19 10:00 [pubmed]
PHST- 2004/10/08 09:00 [medline]
PHST- 2002/01/19 10:00 [entrez]
PST - ppublish
SO  - Zhonghua Nei Ke Za Zhi. 1999 Sep;38(9):619-21.