PMID- 11798982 OWN - NLM STAT- MEDLINE DCOM- 20020314 LR - 20191105 IS - 1523-3774 (Print) IS - 1523-3774 (Linking) VI - 4 IP - 1 DP - 2002 Feb TI - Behcet's disease: immunopathologic and therapeutic aspects. PG - 47-54 AB - Behcet's disease (BD) is a systemic inflammatory disease of unknown etiology. The disease is strongly associated with the human leukocyte antigen (HLA) B51. BD has a chronic course with periodic exacerbations and progressive deterioration. There are no specific diagnostic laboratory tests, although recurrent oral ulceration is an obligatory manifestation for diagnosis. The treatment, which includes local, systemic, or surgical therapies, is based on the severity of the illness; the most appropriate management requires a multidisciplinary approach. This paper summarizes all aspects of BD with particular emphasis on the latest immunologic and treatment aspects. FAU - Meador, Robert AU - Meador R AD - Department of Rheumatology, Hospital of University of Pennsylvania, 3 Ravdin, Suite G, 3400 Spruce Street, Philadelphia, PA, USA. FAU - Ehrlich, George AU - Ehrlich G FAU - Von Feldt, Joan M AU - Von Feldt JM LA - eng PT - Journal Article PT - Review PL - United States TA - Curr Rheumatol Rep JT - Current rheumatology reports JID - 100888970 RN - 0 (Adrenal Cortex Hormones) RN - 0 (Immunosuppressive Agents) SB - IM MH - Adrenal Cortex Hormones/administration & dosage MH - Adult MH - Age Distribution MH - Aged MH - Behcet Syndrome/*diagnosis/epidemiology/*therapy MH - Biopsy, Needle MH - Combined Modality Therapy MH - Female MH - Humans MH - Immunohistochemistry MH - Immunosuppressive Agents/administration & dosage MH - Incidence MH - Male MH - Middle Aged MH - Prognosis MH - Randomized Controlled Trials as Topic MH - Severity of Illness Index MH - Sex Distribution RF - 44 EDAT- 2002/01/19 10:00 MHDA- 2002/03/15 10:01 CRDT- 2002/01/19 10:00 PHST- 2002/01/19 10:00 [pubmed] PHST- 2002/03/15 10:01 [medline] PHST- 2002/01/19 10:00 [entrez] AID - 10.1007/s11926-002-0023-z [doi] PST - ppublish SO - Curr Rheumatol Rep. 2002 Feb;4(1):47-54. doi: 10.1007/s11926-002-0023-z.