PMID- 11801310
OWN - NLM
STAT- MEDLINE
DCOM- 20020226
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 132
IP  - 1
DP  - 2002 Jan 1
TI  - Deletions of 17p13.1 and 13q14 are uncommon in Waldenstrom macroglobulinemia 
      clonal cells and mostly seen at the time of disease progression.
PG  - 55-60
AB  - Waldenstrom macroglobulinemia (WM) is a plasma cell dyscrasia characterized by a 
      monoclonal IgM paraproteinemia. Deletions of 17p13.1 and 13q14 are associated 
      with tumor progression and worsened outcome in multiple myeloma (MM), and we thus 
      investigated WM patients for their presence. Patients (n = 40) were required to 
      have a > or = 1.5 g/dl serum IgM paraproteinemia and a monoclonal 
      lymphoplasmacytic infiltrate. We used interphase fluorescence in situ 
      hybridization (FISH) with probes that localized to 17p13.1(LSI p53/CEP 17) and 
      13q14 (D13S319 and LSI 13 Rb). Of 40 successfully studied patients for 
      17p13.1(p53) deletions, 6 were abnormal, consistent with hemizygous deletion 
      (15%). Of 37 cases successfully studied for the 13q14 deletions, 6 were also 
      abnormal with one pair of signals deleted (16%). Patients with deletions were 
      more likely to be later in the course of the disease. No obvious clinical 
      associations were noted with the exception that patients with 17p13.1(p53) 
      deletions had a higher percent involvement of clonal cells in the bone marrow. 
      Deletions of these two regions are uncommon in WM, being more common in the late 
      stages of the disease, thus unlikely playing a role in primary disease 
      pathogenesis.
FAU - Schop, Roelandt F J
AU  - Schop RF
AD  - Division of Hematology, Mayo Clinic, Rochester, MN 55905, USA.
FAU - Jalal, Syed M
AU  - Jalal SM
FAU - Van Wier, Scott A
AU  - Van Wier SA
FAU - Ahmann, Gregory J
AU  - Ahmann GJ
FAU - Bailey, Richard J
AU  - Bailey RJ
FAU - Kyle, Robert A
AU  - Kyle RA
FAU - Greipp, Philip R
AU  - Greipp PR
FAU - Rajkumar, S Vincent
AU  - Rajkumar SV
FAU - Gertz, Morie A
AU  - Gertz MA
FAU - Lust, John A
AU  - Lust JA
FAU - Lacy, Martha Q
AU  - Lacy MQ
FAU - Dispenzieri, Angela
AU  - Dispenzieri A
FAU - Witzig, Thomas E
AU  - Witzig TE
FAU - Fonseca, Rafael
AU  - Fonseca R
LA  - eng
GR  - CA21115-25C/CA/NCI NIH HHS/United States
GR  - P01 CA62242/CA/NCI NIH HHS/United States
GR  - R01 CA83724-01/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Chromosome Deletion
MH  - Chromosomes, Human, Pair 13/*genetics
MH  - Chromosomes, Human, Pair 17/*genetics
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Interphase/genetics
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Tumor Cells, Cultured/*pathology
MH  - Waldenstrom Macroglobulinemia/diagnosis/*genetics
EDAT- 2002/01/22 10:00
MHDA- 2002/02/28 10:01
CRDT- 2002/01/22 10:00
PHST- 2002/01/22 10:00 [pubmed]
PHST- 2002/02/28 10:01 [medline]
PHST- 2002/01/22 10:00 [entrez]
AID - S016546080100526X [pii]
AID - 10.1016/s0165-4608(01)00526-x [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2002 Jan 1;132(1):55-60. doi: 
      10.1016/s0165-4608(01)00526-x.