PMID- 11801311
OWN - NLM
STAT- MEDLINE
DCOM- 20020226
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 132
IP  - 1
DP  - 2002 Jan 1
TI  - Fluorescence in situ hybridization analysis of the cryptic t(12;21) (p13;q22) in 
      childhood B-lineage acute lymphoblastic leukemia.
PG  - 61-4
AB  - We evaluated retrospectively the cryptic t(12;21)(p13;q22) in 15 children with 
      early B-lineage acute lymphocytic leukemia who had a normal karyotype by using 
      the locus specific probes of TEL and AML1 genes in a dual color fluorescence in 
      situ hybridization (FISH). The FISH analysis revealed six patients with the 
      fusion gene TEL/AML1 on chromosome 21, three of whom possessed a double fusion 
      gene. In addition, the AML1 probe revealed hyperdiploid clones that were not 
      detected in the conventional cytogenetic analysis. A discrepancy between the 
      proportion of cells with the fusion gene in interphase nuclei and metaphases was 
      noted.
FAU - Yehuda-Gafni, Orly
AU  - Yehuda-Gafni O
AD  - Department of Human Genetics, Hadassah Hebrew University Hospital and Medical 
      School, Jerusalem 91120, Israel.
FAU - Cividalli, Gabriel
AU  - Cividalli G
FAU - Abrahmov, Ayala
AU  - Abrahmov A
FAU - Weintrob, Michael
AU  - Weintrob M
FAU - Neriah, Susana Ben
AU  - Neriah SB
FAU - Cohen, Rachel
AU  - Cohen R
FAU - Abeliovich, Dvorah
AU  - Abeliovich D
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (Core Binding Factor Alpha 2 Subunit)
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (TEL-AML1 fusion protein)
SB  - IM
MH  - Burkitt Lymphoma/*genetics
MH  - Child
MH  - Child, Preschool
MH  - Chromosomes, Human, Pair 12/*genetics
MH  - Chromosomes, Human, Pair 21/*genetics
MH  - Core Binding Factor Alpha 2 Subunit
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/methods
MH  - Infant
MH  - Karyotyping
MH  - Male
MH  - Oncogene Proteins, Fusion/genetics
MH  - Retrospective Studies
MH  - Translocation, Genetic/genetics
EDAT- 2002/01/22 10:00
MHDA- 2002/02/28 10:01
CRDT- 2002/01/22 10:00
PHST- 2002/01/22 10:00 [pubmed]
PHST- 2002/02/28 10:01 [medline]
PHST- 2002/01/22 10:00 [entrez]
AID - S0165460801005301 [pii]
AID - 10.1016/s0165-4608(01)00530-1 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2002 Jan 1;132(1):61-4. doi: 
      10.1016/s0165-4608(01)00530-1.