PMID- 11802449
OWN - NLM
STAT- MEDLINE
DCOM- 20020213
LR  - 20190826
IS  - 0030-6622 (Print)
IS  - 0030-6622 (Linking)
VI  - 104
IP  - 12
DP  - 2001 Dec
TI  - [A case report of allergic fungal sinusitis caused by Penicillium sp. and 
      Cladosporium sp].
PG  - 1147-50
AB  - We report a case of allergic fungal sinusitis (AFS) caused by Penicillium sp. and 
      Cladosporium sp. in a 57-year-old man satisfying the following diagnostic 
      criteria: (1) chronic rhinosinusitis revealed by computed tomographic scan, (2) 
      Japanese cedar pollinosis for 3 years, (3) positivity for Penicillium sp. and 
      Cladosporium sp. by a skin test, (4) increased immunoglobulin E (IgE) specific to 
      these fungi, (5) increased total IgE, (6) nasal polyps with severe eosinophilic 
      invasion, (7) allergic mucin revealed by histopathological examination, (8) 
      fungal hyphae revealed by histopathological examination and (9) detection of 
      Penicillium sp. and Cladosporium sp. revealed by fungi culture. The patient was 
      treated by endoscopic sinus surgery. Four weeks after surgery, nasal polyps 
      recurred, but his condition was improved by oral administration of steroids and 
      nebulizer treatment with steroids and fluconazole. Total IgE, specific IgE and 
      eosinophil count in the peripheral blood decreased, apparently reflecting this 
      improvement. After obtaining the patient's consent, we conducted an allergen 
      provocation test, which is as highly diagnostic as a skin test, to test for an 
      antigen causing type I hypersensitivity. The immediate phase response was 
      positive, indicating that type I hypersensitivity intermediated by IgE was 
      involved in AFS.
FAU - Matsuwaki, Y
AU  - Matsuwaki Y
AD  - Department of Otorhinolaryngology, Tokyo Dental College, Ichikawa.
FAU - Nakajima, T
AU  - Nakajima T
FAU - Iida, M
AU  - Iida M
FAU - Nohara, O
AU  - Nohara O
FAU - Haruna, S
AU  - Haruna S
FAU - Moriyama, H
AU  - Moriyama H
LA  - jpn
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Nihon Jibiinkoka Gakkai Kaiho
JT  - Nihon Jibiinkoka Gakkai kaiho
JID - 7505728
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - *Cladosporium
MH  - Humans
MH  - Hypersensitivity, Immediate/*immunology
MH  - Immunoglobulin E/analysis
MH  - Male
MH  - Middle Aged
MH  - Mycoses/*immunology
MH  - *Penicillium
MH  - Sinusitis/*immunology/*microbiology/surgery
EDAT- 2002/01/23 10:00
MHDA- 2002/02/14 10:01
CRDT- 2002/01/23 10:00
PHST- 2002/01/23 10:00 [pubmed]
PHST- 2002/02/14 10:01 [medline]
PHST- 2002/01/23 10:00 [entrez]
AID - 10.3950/jibiinkoka.104.1147 [doi]
PST - ppublish
SO  - Nihon Jibiinkoka Gakkai Kaiho. 2001 Dec;104(12):1147-50. doi: 
      10.3950/jibiinkoka.104.1147.