PMID- 11803118
OWN - NLM
STAT- MEDLINE
DCOM- 20020321
LR  - 20211203
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 318
IP  - 3
DP  - 2002 Feb 1
TI  - Ebselen blocks the quinolinic acid-induced production of thiobarbituric acid 
      reactive species but does not prevent the behavioral alterations produced by 
      intra-striatal quinolinic acid administration in the rat.
PG  - 137-40
AB  - Ebselen (EBS) is a seleno-organic compound with glutathione peroxidase-like 
      activity which is neuroprotective in acute stroke ischemia. In this study, we 
      investigated the effect of EBS on quinolinic acid (QA)-induced neurotoxicity. EBS 
      inhibited QA-induced production of thiobarbituric acid reactive species (TBARS) 
      by striatal homogenates in vitro with an IC(50) of 1.85 microM. Intra-striatal 
      injection of QA (360 nmol) increased striatal content of TBARS and induced 
      convulsions and contralateral rotational behavior. Intra-striatal pre-injection 
      of EBS (10 nmol) 15 min before QA abolished QA-induced TBARS production but did 
      not alter QA-induced behavioral effects. The present findings suggest that EBS 
      acts on post-receptor events, neutralizing free radicals produced by 
      overstimulation of N-methyl-D-aspartate receptors.
FAU - Rossato, Janine I
AU  - Rossato JI
AD  - Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade 
      Federal de Santa Maria, 97105-900, RS, Santa Maria, Brazil.
FAU - Zeni, Gilson
AU  - Zeni G
FAU - Mello, Carlos F
AU  - Mello CF
FAU - Rubin, Maribel A
AU  - Rubin MA
FAU - Rocha, Joao B T
AU  - Rocha JB
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Azoles)
RN  - 0 (Isoindoles)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Organoselenium Compounds)
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - 40X2P7DPGH (ebselen)
RN  - F6F0HK1URN (Quinolinic Acid)
SB  - IM
MH  - Animals
MH  - Azoles/*pharmacology
MH  - Behavior, Animal/drug effects/physiology
MH  - Brain Ischemia/*drug therapy/metabolism/physiopathology
MH  - Drug Interactions/physiology
MH  - Grooming/drug effects/physiology
MH  - Isoindoles
MH  - Lipid Peroxidation/drug effects/physiology
MH  - Motor Activity/drug effects/physiology
MH  - Neostriatum/*drug effects/*metabolism/physiopathology
MH  - Nerve Degeneration/*drug therapy/metabolism/physiopathology
MH  - Neuroprotective Agents/*pharmacology
MH  - Organoselenium Compounds/*pharmacology
MH  - Oxidative Stress/drug effects/physiology
MH  - Quinolinic Acid/*antagonists & inhibitors/metabolism
MH  - Rats
MH  - Reactive Oxygen Species/antagonists & inhibitors/metabolism
MH  - Receptors, N-Methyl-D-Aspartate/drug effects/metabolism
MH  - Thiobarbituric Acid Reactive Substances/*metabolism
MH  - Up-Regulation/drug effects/physiology
EDAT- 2002/01/23 10:00
MHDA- 2002/03/22 10:01
CRDT- 2002/01/23 10:00
PHST- 2002/01/23 10:00 [pubmed]
PHST- 2002/03/22 10:01 [medline]
PHST- 2002/01/23 10:00 [entrez]
AID - S0304394001025046 [pii]
AID - 10.1016/s0304-3940(01)02504-6 [doi]
PST - ppublish
SO  - Neurosci Lett. 2002 Feb 1;318(3):137-40. doi: 10.1016/s0304-3940(01)02504-6.