PMID- 11803451
OWN - NLM
STAT- MEDLINE
DCOM- 20020419
LR  - 20221207
IS  - 1359-4184 (Print)
IS  - 1359-4184 (Linking)
VI  - 7
IP  - 1
DP  - 2002
TI  - Variation in the ESR1 and ESR2 genes and genetic susceptibility to anorexia 
      nervosa.
PG  - 86-9
AB  - There is significant evidence for genetic factors in the susceptibility to 
      anorexia nervosa (AN). Previously genetic variation in the estrogen receptor 2 
      gene (ESR2) has been studied, however no strong evidence of association with AN 
      has been found. In the present study variation in the estrogen receptor 1 (ESR1) 
      and ESR2 genes was examined. Estrogen receptors have been localised to areas of 
      the brain involved in behaviour and regulation of food intake. The anorexic 
      effects of estrogen are accentuated by stress and thus it is postulated that 
      variation in the estrogen receptors may contribute to the genetic susceptibility 
      to AN in females. A cohort of 170 female, Caucasian AN sufferers and 152 female 
      controls were typed for dinucleotide repeat polymorphisms in both ESR1 and ESR2 
      and two further SNPs at each locus. Variation at ESR1 was not associated with AN. 
      However an association was found at the ESR2 locus with the heterozygous genotype 
      of the G1082A polymorphism and AN but not with any of the other ESR2 
      polymorphisms analysed. Analysis of haplotypes at ESR1 and ESR2 showed no 
      significant evidence of association with AN suggesting that the variability in 
      ESR2 alone may contribute to the genetic susceptibility to AN.
FAU - Eastwood, H
AU  - Eastwood H
AD  - Molecular Medicine Unit, University of Leeds, St James's University Hospital, 
      Leeds LS9 7TF, UK. medhg@stjames.leeds.ac.uk
FAU - Brown, K M O
AU  - Brown KM
FAU - Markovic, D
AU  - Markovic D
FAU - Pieri, L F
AU  - Pieri LF
LA  - eng
GR  - MH44292/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Mol Psychiatry
JT  - Molecular psychiatry
JID - 9607835
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (Estrogen Receptor beta)
RN  - 0 (Receptors, Estrogen)
SB  - IM
MH  - Adolescent
MH  - Anorexia Nervosa/epidemiology/*genetics
MH  - Cohort Studies
MH  - *Dinucleotide Repeats
MH  - England/epidemiology
MH  - Estrogen Receptor alpha
MH  - Estrogen Receptor beta
MH  - Exons/genetics
MH  - Feeding Behavior/*physiology
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Polymorphism, Genetic
MH  - *Polymorphism, Single Nucleotide
MH  - Receptors, Estrogen/*genetics/physiology
MH  - White People/genetics
EDAT- 2002/01/23 10:00
MHDA- 2002/04/20 10:01
CRDT- 2002/01/23 10:00
PHST- 2000/11/13 00:00 [received]
PHST- 2001/03/28 00:00 [revised]
PHST- 2001/03/30 00:00 [accepted]
PHST- 2002/01/23 10:00 [pubmed]
PHST- 2002/04/20 10:01 [medline]
PHST- 2002/01/23 10:00 [entrez]
AID - 10.1038/sj.mp.4000929 [doi]
PST - ppublish
SO  - Mol Psychiatry. 2002;7(1):86-9. doi: 10.1038/sj.mp.4000929.