PMID- 11805265
OWN - NLM
STAT- MEDLINE
DCOM- 20020402
LR  - 20190514
IS  - 0028-3878 (Print)
IS  - 0028-3878 (Linking)
VI  - 58
IP  - 2
DP  - 2002 Jan 22
TI  - FADD: A link between TNF family receptors and caspases in Parkinson's disease.
PG  - 308-10
AB  - Fas-associating protein with a death domain (FADD) is a proximal adaptor protein 
      of the tumor necrosis factor (TNF) receptor family death pathway. This human 
      postmortem study showed a significant decrease in the percentage of 
      FADD-immunoreactive dopaminergic (DA) neurons in the substantia nigra pars 
      compacta of patients with PD compared with controls (-24.8%). This decrease 
      correlated with the known selective vulnerability of nigral DA neurons in PD, 
      suggesting that this pathway contributes to the susceptibility of DA neurons in 
      PD to TNF-mediated apoptosis.
FAU - Hartmann, A
AU  - Hartmann A
AD  - Institut National de la Sante et de la Recherche Medicale U 289, Hopital de la 
      Salpetiere, Paris, France.
FAU - Mouatt-Prigent, A
AU  - Mouatt-Prigent A
FAU - Faucheux, B A
AU  - Faucheux BA
FAU - Agid, Y
AU  - Agid Y
FAU - Hirsch, E C
AU  - Hirsch EC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Carrier Proteins)
RN  - 0 (FADD protein, human)
RN  - 0 (Fas-Associated Death Domain Protein)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - EC 3.4.22.- (Caspases)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - *Adaptor Proteins, Signal Transducing
MH  - Aged
MH  - Aged, 80 and over
MH  - Blotting, Western
MH  - Carrier Proteins/*analysis/metabolism
MH  - Caspases/metabolism
MH  - Dopamine/analysis
MH  - Fas-Associated Death Domain Protein
MH  - Humans
MH  - Immunohistochemistry
MH  - Neurons/chemistry
MH  - Parkinson Disease/*metabolism/pathology
MH  - Receptors, Tumor Necrosis Factor/metabolism
MH  - Substantia Nigra/*chemistry/pathology
EDAT- 2002/01/24 10:00
MHDA- 2002/04/03 10:01
CRDT- 2002/01/24 10:00
PHST- 2002/01/24 10:00 [pubmed]
PHST- 2002/04/03 10:01 [medline]
PHST- 2002/01/24 10:00 [entrez]
AID - 10.1212/wnl.58.2.308 [doi]
PST - ppublish
SO  - Neurology. 2002 Jan 22;58(2):308-10. doi: 10.1212/wnl.58.2.308.