PMID- 11808761
OWN - NLM
STAT- MEDLINE
DCOM- 20020221
LR  - 20211203
IS  - 0022-0345 (Print)
IS  - 0022-0345 (Linking)
VI  - 80
IP  - 12
DP  - 2001 Dec
TI  - Association between genetic polymorphism of tumor necrosis factor-alpha and risk 
      of oral submucous fibrosis, a pre-cancerous condition of oral cancer.
PG  - 2055-9
AB  - Many cytokines have been thought to play important roles in the pathogenesis of 
      oral submucous fibrosis (OSF), an areca nut chewing-specific pre-cancerous 
      condition characterized by the deposition of collagen in oral submucosa. Tumor 
      necrosis factor-alpha (TNF-alpha), situated in the class III region of human 
      leukocyte antigen (HLA), is a mediator with multiple functions, including the 
      regulation of inflammatory reaction and transcriptions of collagen and 
      collagenase. In total, 809 male subjects were recruited for assessment of the 
      association of OSF with a bi-allelic promoter-region (-308) polymorphism on the 
      TNFA gene. The high production allele, TNF2, was significantly lower among OSF 
      subjects (n = 166) than in areca-chewing controls (n = 284). This association was 
      independent of oral cancer status. The multivariate-adjusted odds ratio for the 
      TNFA 11 genotype was 2.6 (95% confidence interval = 1.4-4.9; p = 0.004). The 
      finding may imply a multifunctional etiological factor of TNF-alpha in OSF 
      pathogenesis.
FAU - Chiu, C J
AU  - Chiu CJ
AD  - Graduate Institute of Epidemiology, College of Public Health, National Taiwan 
      University,Taipei.
FAU - Chiang, C P
AU  - Chiang CP
FAU - Chang, M L
AU  - Chang ML
FAU - Chen, H M
AU  - Chen HM
FAU - Hahn, L J
AU  - Hahn LJ
FAU - Hsieh, L L
AU  - Hsieh LL
FAU - Kuo, Y S
AU  - Kuo YS
FAU - Chen, C J
AU  - Chen CJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Dent Res
JT  - Journal of dental research
JID - 0354343
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Areca/adverse effects
MH  - Case-Control Studies
MH  - Ethnicity
MH  - Genotype
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Mouth Neoplasms/*genetics
MH  - Odds Ratio
MH  - Oral Submucous Fibrosis/etiology/*genetics
MH  - Polymorphism, Restriction Fragment Length
MH  - Precancerous Conditions/*genetics
MH  - Risk Factors
MH  - Surveys and Questionnaires
MH  - Taiwan
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 2002/01/26 10:00
MHDA- 2002/02/22 10:01
CRDT- 2002/01/26 10:00
PHST- 2002/01/26 10:00 [pubmed]
PHST- 2002/02/22 10:01 [medline]
PHST- 2002/01/26 10:00 [entrez]
AID - 10.1177/00220345010800120601 [doi]
PST - ppublish
SO  - J Dent Res. 2001 Dec;80(12):2055-9. doi: 10.1177/00220345010800120601.