PMID- 11809469 OWN - NLM STAT- MEDLINE DCOM- 20020408 LR - 20220310 IS - 0042-6989 (Print) IS - 0042-6989 (Linking) VI - 42 IP - 2 DP - 2002 Jan TI - Rat retinal ganglion cells co-express brain derived neurotrophic factor (BDNF) and its receptor TrkB. PG - 151-7 AB - The expression of brain derived neurotrophic factor (BDNF) and its preferred receptor (TrkB) in rat retinal ganglion cells (RGCs) have been determined in the present study. To identify RGCs retrograde labelling was performed with fluorogold (FG). Subsequently, retinas were immunostained with antibodies to BDNF and TrkB. We found that all RGCs labelled with FG express both BDNF and its preferred receptor, TrkB. Moreover, displaced amacrine cells were also found to be immunolabelled by both antibodies. Thus BDNF/TrkB signalling in RGCs probably involves endogenous BDNF produced by the RGCs themselves. FAU - Vecino, Elena AU - Vecino E AD - Departamento de Biologia Celular e Histologia, Facultad de Medicina, Universidad del Pais Vasco, E-48940 Leioa, Vizcaya, Spain. gcpvecoe@lg.ehu.es FAU - Garcia-Crespo, David AU - Garcia-Crespo D FAU - Garcia, Monica AU - Garcia M FAU - Martinez-Millan, Luis AU - Martinez-Millan L FAU - Sharma, Sansar C AU - Sharma SC FAU - Carrascal, Eliseo AU - Carrascal E LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Vision Res JT - Vision research JID - 0417402 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Fluorescent Dyes) RN - EC 2.7.10.1 (Receptor, trkB) SB - IM EIN - Vision Res. 2010 Apr 21;50(9):926. Garcia-Grespo, David [corrected to Garcia-Crespo, David] MH - Animals MH - Brain-Derived Neurotrophic Factor/*metabolism MH - Fluorescent Dyes MH - Rats MH - Rats, Sprague-Dawley MH - Receptor, trkB/*metabolism MH - Retinal Ganglion Cells/*metabolism EDAT- 2002/01/26 10:00 MHDA- 2002/04/09 10:01 CRDT- 2002/01/26 10:00 PHST- 2002/01/26 10:00 [pubmed] PHST- 2002/04/09 10:01 [medline] PHST- 2002/01/26 10:00 [entrez] AID - S0042698901002516 [pii] AID - 10.1016/s0042-6989(01)00251-6 [doi] PST - ppublish SO - Vision Res. 2002 Jan;42(2):151-7. doi: 10.1016/s0042-6989(01)00251-6.