PMID- 11809526
OWN - NLM
STAT- MEDLINE
DCOM- 20020515
LR  - 20190720
IS  - 0304-3835 (Print)
IS  - 0304-3835 (Linking)
VI  - 177
IP  - 1
DP  - 2002 Mar 8
TI  - Clinical relevance of cyclin B1 overexpression in laryngeal squamous cell 
      carcinoma.
PG  - 13-9
AB  - Cyclin B1 is a key molecule for G2/M phase transition during the cell cycle and 
      is overexpressed in various human tumors. However, the expression status of 
      cyclin B1 in laryngeal squamous cell carcinoma (LSCC) and its clinical 
      significance remain unknown. We used immunohistochemical studies to examine the 
      expression of cyclin B1 in 102 patients with LSCC. The results showed that cyclin 
      B1 overexpression was observed in 40 cases (39.2%) of LSCCs and was significantly 
      correlated with the tumor site (P=0.031), tumor size (P<0.0001), and advanced 
      stage (P=0.003). In addition, cyclin B1 overexpression was associated with 
      patients' overall survival, but not with disease-free survival using Kaplan-Meier 
      analysis. On multivariate analysis, cyclin B1 expression was not recognized as an 
      independent prognostic factor. These findings indicate that cyclin B1 
      overexpression may be associated with the malignant biological behavior of LSCC.
FAU - Dong, Youyi
AU  - Dong Y
AD  - Department of Physiology, Kagawa Medical University, 1750-1 Ikenobe, Miki-cho, 
      Kita-Gun, Kagawa 761-0793, Japan.
FAU - Sui, Li
AU  - Sui L
FAU - Watanabe, Yasuo
AU  - Watanabe Y
FAU - Sugimoto, Katsuyoshi
AU  - Sugimoto K
FAU - Tokuda, Masaaki
AU  - Tokuda M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Cancer Lett
JT  - Cancer letters
JID - 7600053
RN  - 0 (CCNB1 protein, human)
RN  - 0 (Cyclin B)
RN  - 0 (Cyclin B1)
RN  - 0 (Proliferating Cell Nuclear Antigen)
SB  - IM
MH  - Carcinoma, Squamous Cell/*metabolism/pathology/therapy
MH  - Cyclin B/*metabolism
MH  - Cyclin B1
MH  - Disease-Free Survival
MH  - Female
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Laryngeal Neoplasms/*metabolism/pathology/therapy
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Proliferating Cell Nuclear Antigen/metabolism
MH  - Survival Rate
EDAT- 2002/01/26 10:00
MHDA- 2002/05/16 10:01
CRDT- 2002/01/26 10:00
PHST- 2002/01/26 10:00 [pubmed]
PHST- 2002/05/16 10:01 [medline]
PHST- 2002/01/26 10:00 [entrez]
AID - S0304383501007704 [pii]
AID - 10.1016/s0304-3835(01)00770-4 [doi]
PST - ppublish
SO  - Cancer Lett. 2002 Mar 8;177(1):13-9. doi: 10.1016/s0304-3835(01)00770-4.