PMID- 11811659
OWN - NLM
STAT- MEDLINE
DCOM- 20020619
LR  - 20031114
IS  - 1050-9631 (Print)
IS  - 1050-9631 (Linking)
VI  - 11
IP  - 6
DP  - 2001
TI  - Differences in paired-pulse facilitation and long-term potentiation between 
      dorsal and ventral CA1 regions in anesthetized rats.
PG  - 655-61
AB  - To clarify hippocampal regional differences in synaptic plasticity, paired-pulse 
      facilitation (PPF, a form of short-term plasticity), long-term potentiation (LTP, 
      a form of long-term plasticity), and their interactions were studied in the 
      dorsal and ventral hippocampal CA1 regions of anesthetized rats. Baseline PPF and 
      post-LTP PPF experiments were conducted at interstimulus intervals (ISIs) of 
      20-320 ms. A general protocol (100 Hz, 1 s) and a stronger protocol (250-Hz pulse 
      series) were applied for LTP induction. PPF were observed in both regions; 
      however, the degree was lower and the range of ISIs was narrower in the ventral 
      region compared with the dorsal region. The degree of ventral LTP was lower than 
      that of the dorsal LTP. The interaction between PPF and LTP was observed in both 
      regions (PPF change correlated inversely with degree of baseline PPF). However, 
      this was also different in each region. Dorsal PPF increased or decreased; in 
      contrast, ventral PPF of short ISIs after LTP only decreased. These regional 
      differences in short-term and long-term synaptic plasticity may explain a 
      consequence of different afferent inputs and information processing.
FAU - Maruki, K
AU  - Maruki K
AD  - Department of Neuropsychiatry, Saitama Medical School, Japan. 
      kmaruki@saitama-med.ac.jp
FAU - Izaki, Y
AU  - Izaki Y
FAU - Nomura, M
AU  - Nomura M
FAU - Yamauchi, T
AU  - Yamauchi T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Hippocampus
JT  - Hippocampus
JID - 9108167
SB  - IM
MH  - Animals
MH  - Electric Stimulation/methods
MH  - Evoked Potentials
MH  - Hippocampus/*physiology
MH  - Long-Term Potentiation/*physiology
MH  - Male
MH  - Neuronal Plasticity/physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Synapses/physiology
MH  - Time Factors
EDAT- 2002/01/29 10:00
MHDA- 2002/06/20 10:01
CRDT- 2002/01/29 10:00
PHST- 2002/01/29 10:00 [pubmed]
PHST- 2002/06/20 10:01 [medline]
PHST- 2002/01/29 10:00 [entrez]
AID - 10.1002/hipo.1080 [doi]
PST - ppublish
SO  - Hippocampus. 2001;11(6):655-61. doi: 10.1002/hipo.1080.