PMID- 11815324
OWN - NLM
STAT- MEDLINE
DCOM- 20020212
LR  - 20180330
IS  - 0002-9165 (Print)
IS  - 0002-9165 (Linking)
VI  - 75
IP  - 2
DP  - 2002 Feb
TI  - Habitual physical activity, anabolic hormones, and potassium content of fat-free 
      mass in postmenopausal women.
PG  - 314-20
AB  - BACKGROUND: Total body potassium (TBK) is known to decline throughout adulthood. 
      The relations between physical activity, age, anabolic hormones, and TBK have 
      rarely been considered. OBJECTIVE: We sought to describe the relation between 
      habitual physical activity, age, serum estradiol, and insulin-like growth factor 
      I (IGF-I) and TBK in postmenopausal women. DESIGN: TBK, fat-free mass (FFM), 
      moderate-to-vigorous-intensity physical activity (MVPA; assessed with use of a 
      semistructured interview), and serum concentrations of estradiol, IGF-I, and IGF 
      binding protein 3 (IGFBP-3) were quantified in 51 healthy white women aged 54-76 
      y. RESULTS: The potassium content of FFM declined curvilinearly with age, 
      indicating an accelerated loss of skeletal muscle after 65 y of age. With the 
      data split into high (n = 25) and low (n = 26) MVPA groups, the active women had 
      6.5% more potassium per FFM than did their less-active counterparts (P < 0.01). 
      In multiple regression analysis, MVPA was the major determinant of the potassium 
      content of FFM (P = 0.02), such that an active 70-y-old had the potassium content 
      value of a 55-y-old sedentary woman. Serum estradiol, IGF-I, and IGFBP-3 were not 
      significant determinants of the potassium content of FFM. CONCLUSIONS: These data 
      suggest that 1) habitual physical activity can significantly influence FFM 
      potassium content; 2) physical activity must, therefore, be considered if the 
      effect of aging per se on TBK is to be clarified; and 3) MVPA, such as that 
      pursued by the active women in the present study (eg, walking, dancing, floor 
      exercises, and swimming), can assist in preventing sarcopenia in older women.
FAU - Hansen, Ross D
AU  - Hansen RD
AD  - Centre for In Vivo Body Composition and Gastrointestinal Investigation Unit, The 
      University of Sydney at Royal North Shore Hospital, Sydney, NSW, Australia. 
      hansenr@med.usyd.edu.au
FAU - Allen, Barry J
AU  - Allen BJ
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Clin Nutr
JT  - The American journal of clinical nutrition
JID - 0376027
RN  - 4TI98Z838E (Estradiol)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - RWP5GA015D (Potassium)
SB  - IM
MH  - Adipose Tissue/*metabolism
MH  - Aged
MH  - Aging/metabolism
MH  - *Body Composition
MH  - Estradiol/*blood
MH  - Female
MH  - Humans
MH  - Insulin-Like Growth Factor I/*metabolism
MH  - Middle Aged
MH  - Physical Exertion
MH  - Postmenopause/*blood
MH  - Potassium/*blood
MH  - Regression Analysis
EDAT- 2002/01/30 10:00
MHDA- 2002/02/13 10:01
CRDT- 2002/01/30 10:00
PHST- 2002/01/30 10:00 [pubmed]
PHST- 2002/02/13 10:01 [medline]
PHST- 2002/01/30 10:00 [entrez]
AID - 10.1093/ajcn/75.2.314 [doi]
PST - ppublish
SO  - Am J Clin Nutr. 2002 Feb;75(2):314-20. doi: 10.1093/ajcn/75.2.314.