PMID- 11815592
OWN - NLM
STAT- MEDLINE
DCOM- 20020430
LR  - 20190513
IS  - 0305-7453 (Print)
IS  - 0305-7453 (Linking)
VI  - 49
IP  - 2
DP  - 2002 Feb
TI  - Real-time antifungal susceptibility screening aids management of invasive yeast 
      infections in immunocompromised patients.
PG  - 415-9
AB  - We examined the utility of a semi-solid agar antifungal susceptibility screening 
      (SAAS) test in real-time management of eight immunocompromised patients with 
      invasive yeast infections. Tests of amphotericin B and fluconazole concentrations 
      of 0.5 and 2 mg/L and 1, 8 and 40 mg/L, respectively, were performed on Candida 
      albicans (two), Candida tropicalis (two), Candida krusei (one), Candida glabrata 
      (one) and Trichosporon species (spp.) (two). All but the Trichosporon spp. and C. 
      glabrata isolates were resistant to fluconazole at > or = 40 mg/L, and patients 
      were successfully managed accordingly. Real-time antifungal susceptibility 
      screening can assist in clinical management of invasive yeast infections.
FAU - Hadley, Susan
AU  - Hadley S
AD  - Department of Medicine, Division of Geographic Medicine and Infectious Diseases, 
      New England Medical Center, Box 041, Tufts University School of Medicine, 750 
      Washington Street, Boston, MA 02111, USA. shadley@lifespan.org
FAU - Martinez, Jose A
AU  - Martinez JA
FAU - McDermott, Laura
AU  - McDermott L
FAU - Rapino, Barbara
AU  - Rapino B
FAU - Snydman, David R
AU  - Snydman DR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Antimicrob Chemother
JT  - The Journal of antimicrobial chemotherapy
JID - 7513617
RN  - 0 (Antifungal Agents)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antifungal Agents/*pharmacology/*therapeutic use
MH  - Candida albicans/drug effects/immunology/isolation & purification
MH  - Drug Resistance, Multiple, Bacterial/immunology
MH  - Humans
MH  - Immunocompromised Host/*drug effects
MH  - Microbial Sensitivity Tests/*methods/statistics & numerical data
MH  - Middle Aged
MH  - Mycoses/*drug therapy/immunology
MH  - Trichosporon/drug effects/immunology/isolation & purification
EDAT- 2002/01/30 10:00
MHDA- 2002/05/01 10:01
CRDT- 2002/01/30 10:00
PHST- 2002/01/30 10:00 [pubmed]
PHST- 2002/05/01 10:01 [medline]
PHST- 2002/01/30 10:00 [entrez]
AID - 10.1093/jac/49.2.415 [doi]
PST - ppublish
SO  - J Antimicrob Chemother. 2002 Feb;49(2):415-9. doi: 10.1093/jac/49.2.415.