PMID- 11816828 OWN - NLM STAT- MEDLINE DCOM- 20020403 LR - 20131121 IS - 0904-1850 (Print) IS - 0904-1850 (Linking) VI - 32 DP - 2001 Sep TI - Drug-induced infiltrative lung disease. PG - 93s-100s AB - An increasing number of drugs are recognized to induce distinctive patterns of infiltrative lung disease (ILD), ranging from benign infiltrates to life-threatening adult respiratory distress syndromes. In addition to drugs, biomolecules such as proteins and cytokines, and medicinal plants are also capable of inducing respiratory disease, some being severe and/or irreversible. For several reasons it is difficult to estimate the exact frequency of drug-induced infiltrative lung disease (DI-ILD). The risk for DI-ILD and the clinical patterns vary depending on a variety of host and drug factors. Although establishing the diagnosis is often difficult, systematic evaluation of the possible role of almost any kind of drugs in ILD is warranted, as stopping a drug may favourably influence prognosis. However, prognosis depends on the drug and the type of DI-ILD. Corticosteroids may suppress the inflammatory reaction, but for many drugs, proof of the effect of corticosteroids is lacking. Advances in prevention and prediction are needed. A user-friendly database of respiratory adverse drug reactions was made available on the web, to provide quick information in this area. FAU - Camus, P H AU - Camus PH AD - Service de Pneumologie et de Reanirnation Respiratoire, Centre Hospitalier Universitaire de Dijon, Universite de Bourgogne, France. FAU - Foucher, P AU - Foucher P FAU - Bonniaud, P H AU - Bonniaud PH FAU - Ask, K AU - Ask K LA - eng PT - Journal Article PT - Review PL - England TA - Eur Respir J Suppl JT - The European respiratory journal. Supplement JID - 8910681 SB - IM MH - Drug Hypersensitivity/etiology MH - Drug Therapy/trends MH - Drug-Related Side Effects and Adverse Reactions MH - Europe/epidemiology MH - Forecasting MH - Humans MH - Lung Diseases, Interstitial/*chemically induced/diagnosis MH - Prognosis MH - Risk Factors RF - 151 EDAT- 2002/01/31 10:00 MHDA- 2002/04/04 10:01 CRDT- 2002/01/31 10:00 PHST- 2002/01/31 10:00 [pubmed] PHST- 2002/04/04 10:01 [medline] PHST- 2002/01/31 10:00 [entrez] PST - ppublish SO - Eur Respir J Suppl. 2001 Sep;32:93s-100s.