PMID- 11818028
OWN - NLM
STAT- MEDLINE
DCOM- 20031120
LR  - 20191027
IS  - 1471-2431 (Electronic)
IS  - 1471-2431 (Linking)
VI  - 2
DP  - 2002
TI  - High incidence of Epstein-Barr virus, cytomegalovirus and human herpesvirus 6 
      infections in children with cancer.
PG  - 1
AB  - BACKGROUND: A prospective single-center study was performed to study infection 
      with lymphotropic herpesviruses (LH) Epstein-Barr virus (EBV), cytomegalovirus 
      (CMV) and human herpesvirus 6 (HHV-6) in children with cancer. METHODS: The group 
      of 186 children was examined for the presence of LH before, during and 2 months 
      after the end of anticancer treatment. Serology of EBV and CMV was monitored in 
      all children, serology of HHV-6 and DNA analysis of all three LH was monitored in 
      70 children. RESULTS: At the time of cancer diagnosis (pre-treatment), there was 
      no difference between cancer patients and age-matched healthy controls in overall 
      IgG seropositivity for EBV (68.8% vs. 72.0%; p = 0.47) and CMV (37.6% vs. 41.7%; 
      p = 0.36). During anticancer therapy, primary or reactivated EBV and CMV 
      infection was present in 65 (34.9%) and 66 (35.4%) of 186 patients, respectively, 
      leading to increased overall post-treatment IgG seropositivity that was 
      significantly different from controls for EBV (86.6% vs. 72.0%; p = 0.0004) and 
      CMV (67.7% vs. 41.7%; p < 0.0001). Overall pre-treatment IgG seropositivity for 
      HHV-6 was significantly lower in patients than in controls (80.6% vs. 91.3%; p = 
      0.0231) which may be in agreement with Greaves hypothesis of protective effect of 
      common infections in infancy to cancer development. Primary or reactivated HHV-6 
      infection was present in 23 (32.9%) of 70 patients during anticancer therapy 
      leading to post-treatment IgG seropositivity that was not significantly different 
      from controls (94.3% vs. 91.3%; p = 0.58). The LH infection occurred 
      independently from leukodepleted blood transfusions given. Combination of 
      serology and DNA analysis in detection of symptomatic EBV or CMV infection was 
      superior to serology alone. CONCLUSION: EBV, CMV and HHV-6 infections are 
      frequently present during therapy of pediatric malignancy.
FAU - Michalek, Jaroslav
AU  - Michalek J
AD  - Department of Pediatrics, Division of Hematology/Oncology, Masaryk University, 
      Brno, Czech Republic. jaroslav.michalek@utsouthwestern.edu
FAU - Horvath, Radek
AU  - Horvath R
LA  - eng
PT  - Journal Article
DEP - 20020110
PL  - England
TA  - BMC Pediatr
JT  - BMC pediatrics
JID - 100967804
SB  - IM
MH  - Adolescent
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Comorbidity
MH  - Cytomegalovirus Infections/*epidemiology
MH  - Czech Republic/epidemiology
MH  - Epstein-Barr Virus Infections/*epidemiology
MH  - Female
MH  - Herpesviridae/*isolation & purification
MH  - Herpesvirus 4, Human/isolation & purification
MH  - Herpesvirus 6, Human/isolation & purification
MH  - Humans
MH  - Incidence
MH  - Infant
MH  - Logistic Models
MH  - Male
MH  - Neoplasms/*epidemiology
MH  - Prospective Studies
MH  - Roseolovirus Infections/*epidemiology
PMC - PMC65040
EDAT- 2002/01/31 10:00
MHDA- 2003/12/03 05:00
PMCR- 2002/01/10
CRDT- 2002/01/31 10:00
PHST- 2001/08/04 00:00 [received]
PHST- 2002/01/10 00:00 [accepted]
PHST- 2002/01/31 10:00 [pubmed]
PHST- 2003/12/03 05:00 [medline]
PHST- 2002/01/31 10:00 [entrez]
PHST- 2002/01/10 00:00 [pmc-release]
AID - 1471-2431-2-1 [pii]
AID - 10.1186/1471-2431-2-1 [doi]
PST - ppublish
SO  - BMC Pediatr. 2002;2:1. doi: 10.1186/1471-2431-2-1. Epub 2002 Jan 10.