PMID- 11818703
OWN - NLM
STAT- MEDLINE
DCOM- 20020417
LR  - 20180213
IS  - 1660-8151 (Print)
IS  - 1660-8151 (Linking)
VI  - 90
IP  - 2
DP  - 2002 Feb
TI  - High postdialysis urea rebound can predict intradialytic increase in intraocular 
      pressure in dialysis patients with lowered intradialytic hemoconcentration.
PG  - 181-7
AB  - BACKGROUND: Intradialytic (ID) decrease in intraocular pressure (IOP) parallel to 
      ultrafiltration-induced hemoconcentration has been recently reported. However, 
      exacerbation of glaucoma in hemodialysis (HD) patients during HD sessions is 
      occasionally observed. Postdialysis urea rebound (PDUR) is induced by the lag in 
      urea removal from the cells to urea removal from the extracellular fluid, which 
      when increased can result in ID drag of water to intracellular compartment. It is 
      our hypothesis that similar lag in urea removal from ocular compartments may also 
      be reflected by PDUR, and may induce drag of water into ocular compartments 
      counteracting the effect of hemoconcentration. Our assumption was, therefore, 
      that PDUR might predict ID increase in IOP. METHODS: IOP, serum urea and 
      hematocrit levels were measured at the start, end and 1 h postdialysis, in 19 
      chronic HD patients with normal IOP. RESULTS: PDUR was positively correlated with 
      mean (both eyes) ID changes in IOP (MIDIOP) (r = 0.5, p = 0.03) and % MIDIOP (r = 
      0.55, p = 0.02). ID increase in IOP was observed only in the 7 patients with 
      relatively higher PDUR (> or = 9 mg%), who had also a relatively lower % ID 
      change in Hct (<8%). MIDIOP was negatively correlated with % ID changes in Hct (r 
      = -0.65, p = 0.03) in the 12 patients with PDUR > or = 9 mg, and positively 
      correlated with PDUR (r = 0.57, p = 0.03) in the 14 patients with % ID change in 
      Hct <8%. CONCLUSION: High PDUR may predict susceptibility to ID increase in IOP 
      in patients with lowered ID hemoconcentration.
CI  - Copyright 2002 S. Karger AG, Basel
FAU - Tovbin, David
AU  - Tovbin D
AD  - Department of Nephrology, Soroka Medical Center, Ben-Gurion University, 
      Beer-Sheva, Israel. dtovbin@bgumail.bgu.ac.il
FAU - Belfair, Nadav
AU  - Belfair N
FAU - Shapira, Sorin
AU  - Shapira S
FAU - Rosenthal, Gideon
AU  - Rosenthal G
FAU - Friger, Michel
AU  - Friger M
FAU - Feldman, Leonid
AU  - Feldman L
FAU - Lifshitz, Tova
AU  - Lifshitz T
FAU - Tessler, Zvi
AU  - Tessler Z
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Nephron
JT  - Nephron
JID - 0331777
RN  - 8W8T17847W (Urea)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Glaucoma/diagnosis/*etiology
MH  - Hematocrit
MH  - Humans
MH  - Intraocular Pressure
MH  - Kidney Failure, Chronic/*therapy
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Renal Dialysis/*adverse effects
MH  - Urea/*blood
EDAT- 2002/01/31 10:00
MHDA- 2002/04/18 10:01
CRDT- 2002/01/31 10:00
PHST- 2002/01/31 10:00 [pubmed]
PHST- 2002/04/18 10:01 [medline]
PHST- 2002/01/31 10:00 [entrez]
AID - nef90181 [pii]
AID - 10.1159/000049040 [doi]
PST - ppublish
SO  - Nephron. 2002 Feb;90(2):181-7. doi: 10.1159/000049040.