PMID- 11821655
OWN - NLM
STAT- MEDLINE
DCOM- 20020320
LR  - 20061115
IS  - 0145-6008 (Print)
IS  - 0145-6008 (Linking)
VI  - 26
IP  - 1
DP  - 2002 Jan
TI  - Influence of alcohol consumption on serum immunoglobulin E levels in atopic and 
      nonatopic adults.
PG  - 59-64
AB  - BACKGROUND: Total and specific serum immunoglobulin E (IgE) are routinely used as 
      diagnostic tools in allergy clinics. Several studies have demonstrated an 
      increase of total serum IgE concentrations in alcoholics, but the possible 
      influence of lower quantities of ethanol intake on serum IgE values has not been 
      fully evaluated. This study was aimed at analyzing the influence of alcohol 
      intake on both total and specific serum IgE concentrations in patients studied in 
      an allergy clinic. METHODS: A total of 460 patients were included in the study. 
      According to skin-prick tests to common aeroallergens, 325 were classified as 
      atopics and 135 as nonatopics. Most atopic patients (253; 78%) were allergic to 
      mites. Alcohol consumption was recorded as the number of standard (10-g) drinking 
      units regularly consumed per week. Two hundred subjects (43%) were abstainers, 
      and 260 (57%) were regular consumers of a median of 30 g of alcohol per week. 
      Total serum IgE was measured in all patients by latex-enhanced nephelometry. 
      Serum-specific IgE was assayed by fluoroenzymeimmunoassay. RESULTS: Total serum 
      IgE increased along with ethanol consumption. On multivariate analysis, regular 
      alcohol consumption greater than 70 g per week was associated with increased 
      total serum IgE levels, even when adjusting for age, sex, atopy, and smoking. 
      Among house-dust mite-allergic patients, specific serum IgE values against the 
      house dust mite Dermatophagoides pteronyssinus were higher in regular alcohol 
      consumers than in abstainers. This difference was not observed among patients 
      allergic to grass pollen (Lolium perenne). CONCLUSIONS: Alcohol consumption, even 
      in moderate quantities, is associated with increased total and specific IgE 
      concentrations in subjects studied in an allergy clinic. Alcohol intake should be 
      taken into account in epidemiological studies of total serum IgE levels.
FAU - Vidal, C
AU  - Vidal C
AD  - Department of Allergy, Complejo Hospitalario Universitario de Santiago, Santiago, 
      Spain.
FAU - Armisen, M
AU  - Armisen M
FAU - Dominguez-Santalla, M J
AU  - Dominguez-Santalla MJ
FAU - Gude, F
AU  - Gude F
FAU - Lojo, S
AU  - Lojo S
FAU - Gonzalez-Quintela, A
AU  - Gonzalez-Quintela A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Alcohol Clin Exp Res
JT  - Alcoholism, clinical and experimental research
JID - 7707242
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alcohol Drinking/*blood
MH  - Chi-Square Distribution
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Humans
MH  - Hypersensitivity, Immediate/*immunology
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Statistics, Nonparametric
EDAT- 2002/02/01 10:00
MHDA- 2002/03/21 10:01
CRDT- 2002/02/01 10:00
PHST- 2002/02/01 10:00 [pubmed]
PHST- 2002/03/21 10:01 [medline]
PHST- 2002/02/01 10:00 [entrez]
PST - ppublish
SO  - Alcohol Clin Exp Res. 2002 Jan;26(1):59-64.