PMID- 11821825
OWN - NLM
STAT- MEDLINE
DCOM- 20020306
LR  - 20190916
IS  - 0039-6060 (Print)
IS  - 0039-6060 (Linking)
VI  - 131
IP  - 1 Suppl
DP  - 2002 Jan
TI  - Evaluation of genetic heterogeneity in neuroblastoma.
PG  - S283-7
AB  - BACKGROUND AND METHODS: The prognosis in neuroblastoma, which is the most common 
      solid tumor in children, tends to vary greatly, and many studies have 
      demonstrated both clinical and biological factors to be closely correlated with 
      the outcome. In order to select the optimal treatment according to the degree of 
      malignancy of neuroblastoma, it is essential to accurately and rapidly identify 
      any genetic heterogeneity associated with the prognosis. We assessed the status 
      of some genetic abnormalities (MYCN amplification, deletion of the short arm of 
      chromosome 1, DNA ploidy, and a gain of the chromosome 17q region) associated 
      with the prognosis using several molecular biological methods. RESULTS AND 
      CONCLUSIONS: The combination of several molecular biological techniques is thus 
      considered to be useful for elucidating the degree of malignancy of 
      neuroblastoma. In particular, diagnostic analyses based on a combination of the 
      fluorescence in situ hybridization (FISH) method and the quantitative polymerase 
      chain reaction (PCR) method may be considered to be the most effective methods 
      for quickly and accurately evaluating any aberrations in the gene dosages 
      associated with the patients' outcomes.
FAU - Tajiri, Tatsuro
AU  - Tajiri T
AD  - Department of Pediatric Surgery, Graduate School of Medical Sciences, Kyushu 
      University, Fukuoka, Japan.
FAU - Shono, Kumiko
AU  - Shono K
FAU - Tanaka, Shinji
AU  - Tanaka S
FAU - Suita, Sachiyo
AU  - Suita S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Surgery
JT  - Surgery
JID - 0417347
SB  - IM
MH  - *Chromosomes, Human, Pair 1
MH  - *Chromosomes, Human, Pair 17
MH  - Gene Deletion
MH  - Genetic Heterogeneity
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Neoplasms, Nerve Tissue/*genetics
MH  - Neuroblastoma/*genetics
MH  - Ploidies
MH  - Polymerase Chain Reaction
EDAT- 2002/02/01 10:00
MHDA- 2002/03/07 10:01
CRDT- 2002/02/01 10:00
PHST- 2002/02/01 10:00 [pubmed]
PHST- 2002/03/07 10:01 [medline]
PHST- 2002/02/01 10:00 [entrez]
AID - S0039-6060(02)08857-8 [pii]
AID - 10.1067/msy.2002.119964 [doi]
PST - ppublish
SO  - Surgery. 2002 Jan;131(1 Suppl):S283-7. doi: 10.1067/msy.2002.119964.