PMID- 11824241
OWN - NLM
STAT- MEDLINE
DCOM- 20020320
LR  - 20161021
IS  - 1868-1050 (Print)
IS  - 1868-1050 (Linking)
VI  - 118
DP  - 2001
TI  - [Long-term drug therapy versus antireflux surgery in chronic reflux].
PG  - 177-80
AB  - In endoscopy-negative reflux disease just 25% remain in remission after drug 
      therapy, in reflux oesophagitis only 10%. Long-term management is therefore 
      mandatory in this quality of life-impairing chronic disorder. Following the 
      GENVAL consensus conference proton pump inhibitors (PPI) should be used primarily 
      in a step-down regimen; isomeric PPIs reduce duration of acute therapy by 50%. 
      According to Klinkenberg-Knol et al. 100% of all patients with H2-resistant 
      reflux oesophagitis are asymptomatic and free of recurrency when dosage of PPI is 
      adapted to a higher level. The same result was obtained in the prospective study 
      by Lundell et al. comparing fundoplication and long-term management with 
      omeprazole for 3 years.
FAU - Rosch, W
AU  - Rosch W
AD  - Krankenhaus Nordwest, Steinbacher Hohl 2-26, 60488 Frankfurt/M.
LA  - ger
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
TT  - Medikamentose Dauertherapie versus Antirefluxchirurgie bei der chronischen 
      Refluxkrankheit.
PL  - Germany
TA  - Kongressbd Dtsch Ges Chir Kongr
JT  - Kongressband. Deutsche Gesellschaft fur Chirurgie. Kongress
JID - 100959225
RN  - 0 (Anti-Ulcer Agents)
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Anti-Ulcer Agents/*administration & dosage
MH  - Clinical Trials as Topic
MH  - Esophagitis, Peptic/*drug therapy/surgery
MH  - Fundoplication
MH  - Gastroesophageal Reflux/*drug therapy/surgery
MH  - Humans
MH  - Long-Term Care
MH  - *Proton Pump Inhibitors
MH  - Quality of Life
MH  - Recurrence
MH  - Treatment Outcome
EDAT- 2002/02/05 10:00
MHDA- 2002/03/21 10:01
CRDT- 2002/02/05 10:00
PHST- 2002/02/05 10:00 [pubmed]
PHST- 2002/03/21 10:01 [medline]
PHST- 2002/02/05 10:00 [entrez]
PST - ppublish
SO  - Kongressbd Dtsch Ges Chir Kongr. 2001;118:177-80.