PMID- 11825322
OWN - NLM
STAT- MEDLINE
DCOM- 20020926
LR  - 20190916
IS  - 1465-6566 (Print)
IS  - 1465-6566 (Linking)
VI  - 2
IP  - 11
DP  - 2001 Nov
TI  - COX-2 inhibitors compared and contrasted.
PG  - 1859-76
AB  - Non-steroidal anti-inflammatory drugs (NSAIDs) are the principal drug treatments 
      for inflammation, pain and fever. They act primarily by inhibiting prostaglandin 
      (PG) synthesis but this can cause adverse events (AEs). Since the discovery of 
      two PG synthesising enzymes, COX-1 and COX-2, and the substantial evidence that 
      sparing COX-1 is advantageous for gastric safety, great interest has focused on 
      selective COX-2 inhibitors. Much of the impetus has come from the most recently 
      developed compounds celecoxib and rofecoxib, which have shown spectacular sales 
      growth. However, the older drugs etodolac, nimesulide and meloxicam, made before 
      COX-2 was discovered, are also COX-1-sparing and have good GI safety and 
      therapeutic activities. These five compounds show similarities and differences 
      that are discussed in relation to aspects that include their uses, efficacy, 
      actions and safety.
FAU - Bennett, A
AU  - Bennett A
AD  - Academic Department of Surgery, The Rayne Institute, Guy's, King's and St Thomas' 
      Medical School, King's College, London, SE5 9NU, UK.
FAU - Tavares, I A
AU  - Tavares IA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Review
PL  - England
TA  - Expert Opin Pharmacother
JT  - Expert opinion on pharmacotherapy
JID - 100897346
RN  - 0 (Cyclooxygenase 2 Inhibitors)
RN  - 0 (Cyclooxygenase Inhibitors)
RN  - 0 (Isoenzymes)
RN  - 0 (Membrane Proteins)
RN  - 0 (Prostaglandin Antagonists)
RN  - EC 1.14.99.1 (Cyclooxygenase 2)
RN  - EC 1.14.99.1 (PTGS2 protein, human)
RN  - EC 1.14.99.1 (Prostaglandin-Endoperoxide Synthases)
SB  - IM
MH  - Animals
MH  - Arthritis, Rheumatoid/drug therapy
MH  - Cyclooxygenase 2
MH  - Cyclooxygenase 2 Inhibitors
MH  - Cyclooxygenase Inhibitors/adverse 
      effects/chemistry/economics/pharmacokinetics/*therapeutic use
MH  - Humans
MH  - Isoenzymes/*antagonists & inhibitors
MH  - Membrane Proteins
MH  - Pain/drug therapy
MH  - Prostaglandin Antagonists/pharmacology
MH  - Prostaglandin-Endoperoxide Synthases
MH  - Terminology as Topic
RF  - 159
EDAT- 2002/02/05 10:00
MHDA- 2002/09/27 06:00
CRDT- 2002/02/05 10:00
PHST- 2002/02/05 10:00 [pubmed]
PHST- 2002/09/27 06:00 [medline]
PHST- 2002/02/05 10:00 [entrez]
AID - 10.1517/14656566.2.11.1859 [doi]
PST - ppublish
SO  - Expert Opin Pharmacother. 2001 Nov;2(11):1859-76. doi: 
      10.1517/14656566.2.11.1859.