PMID- 11825624
OWN - NLM
STAT- MEDLINE
DCOM- 20020523
LR  - 20191105
IS  - 0188-4409 (Print)
IS  - 0188-4409 (Linking)
VI  - 33
IP  - 1
DP  - 2002 Jan-Feb
TI  - Neuroprotective effects of progesterone on damage elicited by acute global 
      cerebral ischemia in neurons of the caudate nucleus.
PG  - 6-14
AB  - BACKGROUND: In addition to the hippocampus, the dorsolateral caudate nucleus (CN) 
      and the pars reticularis of the substantia nigra (SNr) are among the most 
      vulnerable brain areas to ischemia. A possible association of the neuronal injury 
      in these two subcortical nuclei has been proposed, the primary damage affecting 
      the CN GABAergic neurons innervating the SNr, and secondarily the SNr neurons as 
      a result of an imbalance of GABAergic and glutamatergic input to the SNr. 
      Progesterone (P(4)) exerts a GABAergic action on the central nervous system (CNS) 
      and is known to protect neurons in the cat hippocampus from the damaging effect 
      of acute global cerebral ischemia (AGCI). The effects of AGCI on the neuronal 
      populations of the CN and SNr, in addition to the possible neuroprotective 
      effects of P(4), were assessed in cats in the present study. METHODS: 
      Ovariectomized adult cats were treated subcutaneously (s.c.) with either P(4) (10 
      mg/kg/day) or corn oil during the 7 days before and 7 days after being subjected 
      to a period of AGCI by 15 min of cardiorespiratory arrest followed by 4 min of 
      reanimation. After 14 days of survival, animals were sacrificed and their brains 
      perfused in situ with phosphate-buffered 10% formaldehyde for histologic 
      examination. RESULTS: ACGI resulted in an intense glial reaction in the CN and a 
      significant loss (43%) of medium-sized neurons of the CN, but no difference was 
      found in the densities of SNr neurons between controls and ischemic oil- and 
      P(4)-treated cats. Progesterone treatment completely prevented CN neuronal loss. 
      CONCLUSIONS: The overall results point to the higher vulnerability of CN neurons 
      to ischemia as compared to neurons in the SNr and show the protective effects of 
      P(4) upon CN neuronal damage after ischemia.
FAU - Cervantes, Miguel
AU  - Cervantes M
AD  - Laboratorio de Neurofarmacologia, Centro de Investigacion Biomedica de Michoacan, 
      Instituto Mexicano del Seguro Social (IMSS), Morelia, Michoacan, Mexico.
FAU - Gonzalez-Vidal, Maria Dolores
AU  - Gonzalez-Vidal MD
FAU - Ruelas, Rodrigo
AU  - Ruelas R
FAU - Escobar, Alfonso
AU  - Escobar A
FAU - Morali, Gabriela
AU  - Morali G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Arch Med Res
JT  - Archives of medical research
JID - 9312706
RN  - 0 (Neuroprotective Agents)
RN  - 4G7DS2Q64Y (Progesterone)
SB  - IM
MH  - Animals
MH  - Brain Ischemia/*pathology/physiopathology
MH  - Cats
MH  - Caudate Nucleus/drug effects/*pathology
MH  - Female
MH  - Heart Arrest
MH  - Neurons/*drug effects/metabolism
MH  - Neuroprotective Agents/administration & dosage/*pharmacology
MH  - Ovariectomy
MH  - Progesterone/administration & dosage/*pharmacology
MH  - Random Allocation
MH  - Substantia Nigra/drug effects/*pathology
EDAT- 2002/02/05 10:00
MHDA- 2002/05/25 10:01
CRDT- 2002/02/05 10:00
PHST- 2002/02/05 10:00 [pubmed]
PHST- 2002/05/25 10:01 [medline]
PHST- 2002/02/05 10:00 [entrez]
AID - S0188-4409(01)00347-2 [pii]
AID - 10.1016/s0188-4409(01)00347-2 [doi]
PST - ppublish
SO  - Arch Med Res. 2002 Jan-Feb;33(1):6-14. doi: 10.1016/s0188-4409(01)00347-2.