PMID- 11826016
OWN - NLM
STAT- MEDLINE
DCOM- 20020312
LR  - 20190503
IS  - 1468-6244 (Electronic)
IS  - 0022-2593 (Print)
IS  - 0022-2593 (Linking)
VI  - 39
IP  - 1
DP  - 2002 Jan
TI  - Familial adult renal neoplasia.
PG  - 1-5
AB  - Our understanding of the molecular mechanisms underlying the tumorigenesis of 
      renal cell carcinoma (RCC) has partially come from studies of RCC related 
      familial cancer syndromes such as von Hippel-Lindau (VHL) disease and hereditary 
      papillary RCC (HPRC). These studies have led to the identification of RCC related 
      genes, which, besides allowing accurate diagnosis of these diseases, have been 
      found mutated or abnormally expressed in the sporadic counterparts of these 
      familial renal tumours. To date, a number of renal tumour related syndromes have 
      been described. We review recent advances in this field and discuss a genetic 
      approach to managing familial cases of renal tumours occasionally encountered by 
      cancer geneticists and urologists.
FAU - Takahashi, M
AU  - Takahashi M
AD  - Laboratory of Cancer Genetics, Van Andel Research Institute, Grand Rapids, MI 
      49503, USA.
FAU - Kahnoski, R
AU  - Kahnoski R
FAU - Gross, D
AU  - Gross D
FAU - Nicol, D
AU  - Nicol D
FAU - Teh, B T
AU  - Teh BT
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Med Genet
JT  - Journal of medical genetics
JID - 2985087R
SB  - IM
MH  - Adult
MH  - *Carcinoma, Papillary/genetics/pathology
MH  - *Carcinoma, Renal Cell/genetics/pathology
MH  - Genotype
MH  - Humans
MH  - *Kidney Neoplasms/genetics/pathology
MH  - Phenotype
MH  - *von Hippel-Lindau Disease/genetics/pathology
PMC - PMC1734964
EDAT- 2002/02/05 10:00
MHDA- 2002/03/13 10:01
PMCR- 2005/01/01
CRDT- 2002/02/05 10:00
PHST- 2002/02/05 10:00 [pubmed]
PHST- 2002/03/13 10:01 [medline]
PHST- 2002/02/05 10:00 [entrez]
PHST- 2005/01/01 00:00 [pmc-release]
AID - 10.1136/jmg.39.1.1 [doi]
PST - ppublish
SO  - J Med Genet. 2002 Jan;39(1):1-5. doi: 10.1136/jmg.39.1.1.