PMID- 11826106
OWN - NLM
STAT- MEDLINE
DCOM- 20020227
LR  - 20191023
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 22
IP  - 3
DP  - 2002 Feb 1
TI  - Novel microglomerular structures in the olfactory bulb of mice.
PG  - 766-74
AB  - The murine olfactory system consists of two primary divisions: (1) a main 
      olfactory system, in which olfactory sensory neurons (OSNs) located in the main 
      olfactory epithelium (MOE) send their axons to glomeruli in the main olfactory 
      bulb (MOB); and (2) an accessory olfactory system, in which OSNs located in the 
      vomeronasal organ send their axons to glomeruli in the accessory olfactory bulb 
      (AOB). In labeling studies using the lectin Ulex europaeus agglutinin (UEA), we 
      discovered a novel subset of small neuropilar structures in the MOB that are 
      distinct from other glomeruli both in the MOB and AOB. These "microglomeruli" are 
      morphologically similar to MOB glomeruli in many respects: they receive 
      innervation from processes present in the olfactory nerve layer and are isolated 
      from other glomeruli by juxtaglomerular cells; in addition, the compartmental 
      pattern of UEA labeling suggests the presence of UEA (-) processes within their 
      neuropil. Microglomeruli contained processes that express the olfactory marker 
      protein, a marker common to mature OSN axons. However, unlike other glomerular 
      structures, the microglomeruli did not contain neural cell adhesion 
      molecule-labeled processes. Within microglomeruli, UEA(+) processes 
      interdigitated with MAP2(+) dendrites, some of which likely originate from 
      interneurons, as indicated by glutamic acid decarboxylase labeling. Synaptophysin 
      labeling in microglomeruli strongly suggested that synapses occur between UEA(+) 
      processes and dendrites. Anterograde labeling of OSNs, by injection of 
      rhodamine-dextran into one naris, demonstrated that UEA(+) processes in 
      microglomeruli originated in the MOE. The unique morphology, protein expression, 
      and location of microglomeruli have led us to hypothesize that they represent a 
      novel class of glomerular structures in the murine olfactory system.
FAU - Lipscomb, Brian W
AU  - Lipscomb BW
AD  - Interdepartmental Neuroscience Graduate Program, Department of Neurosurgery, and 
      Section of Neurobiology, Yale University School of Medicine, New Haven, 
      Connecticut 06520, USA.
FAU - Treloar, Helen B
AU  - Treloar HB
FAU - Greer, Charles A
AU  - Greer CA
LA  - eng
GR  - DC00210/DC/NIDCD NIH HHS/United States
GR  - NS10174/NS/NINDS NIH HHS/United States
GR  - R01 DC000210/DC/NIDCD NIH HHS/United States
GR  - DC03887/DC/NIDCD NIH HHS/United States
GR  - F05 NS010174/NS/NINDS NIH HHS/United States
GR  - F32 DC000210/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Antigens, Differentiation)
RN  - 0 (Lectins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neural Cell Adhesion Molecules)
RN  - 0 (Olfactory Marker Protein)
RN  - 0 (Omp protein, mouse)
RN  - 0 (Plant Lectins)
RN  - 0 (Ulex europaeus lectins)
SB  - IM
MH  - Animals
MH  - Animals, Outbred Strains
MH  - Antigens, Differentiation/biosynthesis
MH  - Axons/ultrastructure
MH  - Dendrites/ultrastructure
MH  - Female
MH  - Immunohistochemistry
MH  - Lectins
MH  - Mice
MH  - Nerve Tissue Proteins/biosynthesis
MH  - Neural Cell Adhesion Molecules/metabolism
MH  - Neuropil/metabolism/*ultrastructure
MH  - Olfactory Bulb/metabolism/*ultrastructure
MH  - Olfactory Marker Protein
MH  - *Plant Lectins
MH  - Synapses/ultrastructure
PMC - PMC6758479
EDAT- 2002/02/05 10:00
MHDA- 2002/02/28 10:01
PMCR- 2002/08/01
CRDT- 2002/02/05 10:00
PHST- 2002/02/05 10:00 [pubmed]
PHST- 2002/02/28 10:01 [medline]
PHST- 2002/02/05 10:00 [entrez]
PHST- 2002/08/01 00:00 [pmc-release]
AID - 22/3/766 [pii]
AID - 6020 [pii]
AID - 10.1523/JNEUROSCI.22-03-00766.2002 [doi]
PST - ppublish
SO  - J Neurosci. 2002 Feb 1;22(3):766-74. doi: 10.1523/JNEUROSCI.22-03-00766.2002.