PMID- 11828995
OWN - NLM
STAT- MEDLINE
DCOM- 20020717
LR  - 20190916
IS  - 0300-5623 (Print)
IS  - 0300-5623 (Linking)
VI  - 29
IP  - 6
DP  - 2001 Dec
TI  - Lack of evidence for the association of tumor necrosis factor-alpha gene promoter 
      polymorphism with calcium oxalate stone and bladder cancer patients.
PG  - 412-6
AB  - Urinary stone disease and bladder cancer are two of the most commonly seen 
      urologic diseases in Taiwan. Tumor necrosis factor-alpha (TNF-alpha) is one of 
      the cytokines secreted by macrophages and is related to a sequence of events in 
      response to inflammation and cancer formation. We investigated the polymorphism 
      of the TNF-alpha gene promoter -308 as a genetic marker in searching for the 
      association between these two commonly seen urologic diseases. One hundred and 
      fourteen patients with transitional cell carcinoma of the urinary bladder and 103 
      patients with calcium oxalate stone were compared with 150 healthy controls. The 
      polymorphism was detected by polymerase chain reaction-based restriction analysis 
      (Nco I endonuclease). The results revealed no significant differences between 
      normal individuals and the patients with the two commonly seen urologic diseases 
      (P > 0.05). We concluded that the polymorphism of the TNF-alpha promoter -308 is 
      not a valid genetic marker for these two urologic diseases.
FAU - Tsai, F J
AU  - Tsai FJ
AD  - Department of Medical Genetics, China Medical College Hospital, China Medical 
      College, Taichung, Taiwan.
FAU - Lu, H F
AU  - Lu HF
FAU - Yeh, L S
AU  - Yeh LS
FAU - Hsu, C D
AU  - Hsu CD
FAU - Chen, W C
AU  - Chen WC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Urol Res
JT  - Urological research
JID - 0364311
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 2612HC57YE (Calcium Oxalate)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Calcium Oxalate/urine
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic/*genetics
MH  - Tumor Necrosis Factor-alpha/*genetics
MH  - Urinary Bladder Neoplasms/*genetics
MH  - Urinary Calculi/*genetics
EDAT- 2002/02/07 10:00
MHDA- 2002/07/18 10:01
CRDT- 2002/02/07 10:00
PHST- 2002/02/07 10:00 [pubmed]
PHST- 2002/07/18 10:01 [medline]
PHST- 2002/02/07 10:00 [entrez]
AID - 10.1007/s002400100219 [doi]
PST - ppublish
SO  - Urol Res. 2001 Dec;29(6):412-6. doi: 10.1007/s002400100219.