PMID- 11831547
OWN - NLM
STAT- MEDLINE
DCOM- 20020724
LR  - 20220309
IS  - 0893-7648 (Print)
IS  - 0893-7648 (Linking)
VI  - 24
IP  - 1-3
DP  - 2001 Aug-Dec
TI  - Anterograde axonal transport, transcytosis, and recycling of neurotrophic 
      factors: the concept of trophic currencies in neural networks.
PG  - 1-28
AB  - Traditional views of neurotrophic factor biology held that trophic factors are 
      released from target cells, retrogradely transported along their axons, and 
      rapidly degraded upon arrival in cell bodies. Increasing evidence indicates that 
      several trophic factors such as brain-derived neurotrophic factor (BDNF), 
      fibroblast growth factor (FGF-2), glial cell-line derived neurotrophic factor 
      (GDNF), insulin-like growth factor (IGF-I), and neurotrophin-3 (NT-3), can move 
      anterogradely along axons. They can escape the degradative pathway upon 
      internalization and are recycled for future uses. Internalized ligands can move 
      through intermediary cells by transcytosis, presumably by endocytosis via 
      endosomes to the Golgi system, by trafficking of the factor to dendrites or by 
      sorting into anterograde axonal transport with subsequent release from axon 
      terminals and uptake by second- or third-order target neurons. Such data suggest 
      the existence of multiple "trophic currencies," which may be used over several 
      steps in neural networks to enable nurturing relationships between connected 
      neurons or glial cells, not unlike currency exchanges between trading partners in 
      the world economy. Functions of multistep transfer of trophic material through 
      neural networks may include regulation of neuronal survival, differentiation of 
      phenotypes and dendritic morphology, synapse plasticity, as well as excitatory 
      neurotransmission. The molecular mechanisms of sorting, trafficking, and release 
      of trophic factors from distinct neuronal compartments are important for an 
      understanding of neurotrophism, but they present challenging tasks owing to the 
      low levels of the endogenous factors.
FAU - von Bartheld, C S
AU  - von Bartheld CS
AD  - Department of Physiology and Cell Biology, University of Nevada School of 
      Medicine, Reno 89557, USA. chrisvb@physio.unr.edu
FAU - Wang, X
AU  - Wang X
FAU - Butowt, R
AU  - Butowt R
LA  - eng
GR  - HD 29177/HD/NICHD NIH HHS/United States
GR  - NS 35931/NS/NINDS NIH HHS/United States
GR  - NS 35931S2/NS/NINDS NIH HHS/United States
GR  - TW 05700/TW/FIC NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Mol Neurobiol
JT  - Molecular neurobiology
JID - 8900963
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Animals
MH  - Axonal Transport
MH  - Biological Transport
MH  - *Cell Physiological Phenomena
MH  - Nerve Growth Factor/*metabolism
MH  - Protein Transport
MH  - Rats
RF  - 210
EDAT- 2002/02/08 10:00
MHDA- 2002/07/26 10:01
CRDT- 2002/02/08 10:00
PHST- 2002/02/08 10:00 [pubmed]
PHST- 2002/07/26 10:01 [medline]
PHST- 2002/02/08 10:00 [entrez]
AID - MN:24:1-3:001 [pii]
AID - 10.1385/MN:24:1-3:001 [doi]
PST - ppublish
SO  - Mol Neurobiol. 2001 Aug-Dec;24(1-3):1-28. doi: 10.1385/MN:24:1-3:001.