PMID- 11832124
OWN - NLM
STAT- MEDLINE
DCOM- 20050114
LR  - 20061115
IS  - 0529-5815 (Print)
IS  - 0529-5815 (Linking)
VI  - 38
IP  - 8
DP  - 2000 Aug
TI  - [Relationship between estrogen receptor and Graves' disease].
PG  - 619-21
AB  - OBJECTIVE: To study the relation of expression of estrogen receptor (ER) in 
      thyroid tissues with Graves' disease (GD). METHODS: ER was detected in the 
      tissues of 40 patients with GD and 15 patients with normal thyroid by 
      immunohistochemical method. Gene expression of ER was studied in frozen slides of 
      26 GD thyroids and 10 normal thyroids by fluorescence in situ hybridization 
      (FISH) together with image analysis system. RESULTS: In immunohistochemical 
      detection, the positive rate of ER in GD group was 70% (28/40), but 13.3% (2/15) 
      in the control group (P < 0.01). The positive degree of ER in female with GD was 
      higher than that in male with GD (P < 0.05). The positive rate of ER in the 
      female GD group below 35 years was 85.0% (17/20) and 50% (5/10) in the female GD 
      group above 35 years (P < 0.05). In FISH, the optical density (A) value of the 
      female GD group was 30.14 +/- 10.74, and in the male GD group 21.06 +/- 7.71, but 
      in the control group it was 16.91 +/- 5.30 (P < 0.01). The A value of the female 
      GD group below 35 years was 33.85 +/- 10.10, and 23.24 +/- 7.48 in the female GD 
      group above 35 years (P < 0.05). CONCLUSIONS: The increasing of ER content is 
      related to the development of GD. Estrogen may be a promoting factor for GD. The 
      sex and age differences in GD development are associated with the effects of 
      estrogen and ER.
FAU - Wang, S
AU  - Wang S
AD  - Department of General Surgery, First Affiliated Hospital, Sun Yan-sen University 
      of Medical Sciences, Guangzhou 510080, China.
FAU - Mao, S
AU  - Mao S
FAU - Zhao, G
AU  - Zhao G
FAU - Wu, H
AU  - Wu H
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Wai Ke Za Zhi
JT  - Zhonghua wai ke za zhi [Chinese journal of surgery]
JID - 0153611
RN  - 0 (Estrogens)
RN  - 0 (Receptors, Estrogen)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Estrogens/metabolism
MH  - Female
MH  - Graves Disease/*metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization
MH  - Male
MH  - Middle Aged
MH  - Receptors, Estrogen/*metabolism
MH  - Sex Factors
MH  - Thyroid Gland/*metabolism
EDAT- 2002/02/08 10:00
MHDA- 2005/01/15 09:00
CRDT- 2002/02/08 10:00
PHST- 2002/02/08 10:00 [pubmed]
PHST- 2005/01/15 09:00 [medline]
PHST- 2002/02/08 10:00 [entrez]
PST - ppublish
SO  - Zhonghua Wai Ke Za Zhi. 2000 Aug;38(8):619-21.