PMID- 11832226
OWN - NLM
STAT- MEDLINE
DCOM- 20020305
LR  - 20191210
IS  - 0896-6273 (Print)
IS  - 0896-6273 (Linking)
VI  - 33
IP  - 3
DP  - 2002 Jan 31
TI  - A calcium-responsive transcription factor, CaRF, that regulates neuronal 
      activity-dependent expression of BDNF.
PG  - 383-95
AB  - Transcription of the brain-derived neurotrophic factor (BDNF) gene is regulated 
      in a calcium- and neuron-selective manner; however, the mechanisms that underlie 
      this selectivity are not known. We have characterized a new calcium-response 
      element, CaRE1, that is required for activity-dependent transcription of BDNF 
      exon III and have cloned a transcription factor, CaRF, that activates 
      transcription from BDNF promoter III in a CaRE1-dependent manner. The 
      transcriptional activity of CaRF is regulated in a calcium- and neuron-selective 
      manner, suggesting that CaRF may confer selectivity upon the activity-dependent 
      induction of BDNF exon III expression.
FAU - Tao, Xu
AU  - Tao X
AD  - Division of Neuroscience, Children's Hospital, Boston, MA 02115, USA.
FAU - West, Anne E
AU  - West AE
FAU - Chen, Wen G
AU  - Chen WG
FAU - Corfas, Gabriel
AU  - Corfas G
FAU - Greenberg, Michael E
AU  - Greenberg ME
LA  - eng
SI  - GENBANK/AF454946
SI  - GENBANK/AF454947
GR  - HD18655/HD/NICHD NIH HHS/United States
GR  - NS28829-07/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (CaRF protein, human)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Phosphodiesterase Inhibitors)
RN  - 0 (Transcription Factors)
RN  - E0399OZS9N (Cyclic AMP)
RN  - SY7Q814VUP (Calcium)
RN  - TBT296U68M (1-Methyl-3-isobutylxanthine)
SB  - IM
CIN - Neuron. 2002 Jan 31;33(3):315-6. PMID: 11832218
MH  - 1-Methyl-3-isobutylxanthine/pharmacology
MH  - Amino Acid Sequence
MH  - Animals
MH  - Brain/cytology/metabolism
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Calcium/metabolism
MH  - Cells, Cultured
MH  - Cyclic AMP/analogs & derivatives/metabolism
MH  - DNA-Binding Proteins
MH  - Exons/genetics
MH  - Gene Expression Regulation/*physiology
MH  - Genes, Reporter
MH  - Humans
MH  - In Situ Hybridization
MH  - Microscopy, Fluorescence
MH  - Molecular Sequence Data
MH  - Neurons/cytology/drug effects/*metabolism
MH  - Nuclear Proteins/metabolism
MH  - Phosphodiesterase Inhibitors/pharmacology
MH  - Rats
MH  - Rats, Long-Evans
MH  - Regulatory Sequences, Nucleic Acid/genetics
MH  - Response Elements/*genetics
MH  - Tissue Distribution
MH  - Transcription Factors/chemistry/*metabolism
MH  - Two-Hybrid System Techniques
EDAT- 2002/02/08 10:00
MHDA- 2002/03/07 10:01
CRDT- 2002/02/08 10:00
PHST- 2002/02/08 10:00 [pubmed]
PHST- 2002/03/07 10:01 [medline]
PHST- 2002/02/08 10:00 [entrez]
AID - S089662730100561X [pii]
AID - 10.1016/s0896-6273(01)00561-x [doi]
PST - ppublish
SO  - Neuron. 2002 Jan 31;33(3):383-95. doi: 10.1016/s0896-6273(01)00561-x.