PMID- 11833417
OWN - NLM
STAT- MEDLINE
DCOM- 20021107
LR  - 20141120
IS  - 0371-0874 (Print)
IS  - 0371-0874 (Linking)
VI  - 53
IP  - 5
DP  - 2001 Oct
TI  - [5-HT3 receptors in amygdala mediate neuroimmunomodulation in rats].
PG  - 349-54
AB  - The present study was to explore the possible immunomodulatory role of 5-HT3 
      receptors in the amygdala in rats. Concanovalin A (Con A)- and lipopolysaccharide 
      (LPS)-stimulated splenocyte proliferation response (SPR), production of IL-2, 
      activity of natural killer (NK) cells and serum cortisol were measured by 3H-TdR 
      incorporating method, MTT method and RIA, respectively. The Con A- and 
      LPS-stimulated SPR was enhanced in a dose-dependent manner by 5-HT3 receptor 
      antagonist granisetron (GNT) (0.1-0.4 mg/kg, i.p.). SPR was also enhanced by 
      intracerebroventricular (icv) administration of 1-phenylbiguanide (PBG, 10 
      micrograms/d). Con A-stimulated SPR and production of IL-2 were increased either 
      by bilateral or by unilateral central amygdala (CeA) microinfusion of PBG (0.5 
      microgram/side), but LPS-induced SPR and NK cell activity were not affected. On 
      the contrary, the LPS-induced SPR was increased by either bilateral or unilateral 
      basomedial amygdala (BmA) microinfusion of PBG (0.5 microgram/side). The plasma 
      cortisol level was significantly raised by CeA or BmA PBG microinfusion, but the 
      effect induced by PBG intra-CeA was greater than that induced by PBG intra-BmA (P 
      < 0.01). The effects of icv PBG and intra-amygdala infusion were antagonized by 
      granisetron. Asymmetrical modulation of immune reactivity by 5-HT3 receptors in 
      CeA or BmA was not observed in these experiments. It is suggested that 5-HT3 
      receptors within the amygdala may modulate rat mitogen-stimulated SPR in 
      different manners.
FAU - Xu, D Y
AU  - Xu DY
AD  - Department of Pharmacology, School of Basic Medical Science, Southeast 
      University, Nanjing 210009. xdysouth@263.net
FAU - Jia, H B
AU  - Jia HB
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Sheng Li Xue Bao
JT  - Sheng li xue bao : [Acta physiologica Sinica]
JID - 20730130R
RN  - 0 (Interleukin-2)
RN  - 0 (Receptors, Serotonin)
SB  - IM
MH  - Amygdala/*immunology/metabolism
MH  - Animals
MH  - Female
MH  - In Vitro Techniques
MH  - Interleukin-2/biosynthesis
MH  - Male
MH  - Neuroimmunomodulation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Serotonin/*immunology/metabolism
MH  - Spleen/immunology
EDAT- 2002/02/09 10:00
MHDA- 2002/11/26 04:00
CRDT- 2002/02/09 10:00
PHST- 2002/02/09 10:00 [pubmed]
PHST- 2002/11/26 04:00 [medline]
PHST- 2002/02/09 10:00 [entrez]
PST - ppublish
SO  - Sheng Li Xue Bao. 2001 Oct;53(5):349-54.