PMID- 11833737
OWN - NLM
STAT- MEDLINE
DCOM- 20020222
LR  - 20230817
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 70
IP  - 7
DP  - 2002 Jan 4
TI  - Role for brain-derived neurotrophic factor in learning and memory.
PG  - 735-44
AB  - In addition to its actions on neuronal survival and differentiation, 
      brain-derived neurotrophic factor (BDNF) has a role in the regulation of synaptic 
      strength. Long-term potentiation, a form of synaptic plasticity, is markedly 
      impaired in BDNF mutant mice, but the changes were restored by the re-expression 
      of BDNF. BDNF also influences the development of patterned connections and the 
      growth and complexity of dendrites in the cerebral cortex. These results suggest 
      a role for BDNF in learning and memory processes, since memory acquisition is 
      considered to involve both short-term changes in electrical properties and 
      long-term structural alterations in synapses. Memory acquisition is associated 
      with an increase in BDNF mRNA and TrkB receptor activation in specific brain 
      areas. Moreover, the pharmacologic and genetic deprivation of BDNF or its 
      receptor TrkB results in severe impairment of learning and memory in mice, rats 
      and chicks. The effect of BDNF on learning and memory may be linked to the 
      modulation of NMDA and non-NMDA receptor functions as well as the expression of 
      synaptic proteins required for exocytosis. Activation of the mitogen-associated 
      protein kinase and/or phosphatidylinositol 3-kinase signaling pathways may be 
      involved in BDNF-dependent learning and memory formation. It is concluded that 
      BDNF/TrkB signaling plays an important role in learning and memory.
FAU - Yamada, Kiyofumi
AU  - Yamada K
AD  - Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University 
      Graduate School of Medicine, Japan.
FAU - Mizuno, Makoto
AU  - Mizuno M
FAU - Nabeshima, Toshitaka
AU  - Nabeshima T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*physiology
MH  - Learning/*physiology
MH  - Long-Term Potentiation/physiology
MH  - Memory/*physiology
MH  - Mice
MH  - Mice, Mutant Strains
MH  - Receptor, trkB/genetics/metabolism
RF  - 68
EDAT- 2002/02/09 10:00
MHDA- 2002/02/23 10:01
CRDT- 2002/02/09 10:00
PHST- 2002/02/09 10:00 [pubmed]
PHST- 2002/02/23 10:01 [medline]
PHST- 2002/02/09 10:00 [entrez]
AID - S0024-3205(01)01461-8 [pii]
AID - 10.1016/s0024-3205(01)01461-8 [doi]
PST - ppublish
SO  - Life Sci. 2002 Jan 4;70(7):735-44. doi: 10.1016/s0024-3205(01)01461-8.