PMID- 11835276
OWN - NLM
STAT- MEDLINE
DCOM- 20020701
LR  - 20071115
IS  - 0265-9247 (Print)
IS  - 0265-9247 (Linking)
VI  - 24
IP  - 2
DP  - 2002 Feb
TI  - Control of developmental timing by small temporal RNAs: a paradigm for 
      RNA-mediated regulation of gene expression.
PG  - 119-29
AB  - Heterochronic genes control the timing of developmental programs. In C. elegans, 
      two key genes in the heterochronic pathway, lin-4 and let-7, encode small 
      temporally expressed RNAs (stRNAs) that are not translated into protein. These 
      stRNAs exert negative post-transcriptional regulation by binding to complementary 
      sequences in the 3' untranslated regions of their target genes. stRNAs are 
      transcribed as longer precursor RNAs that are processed by the RNase Dicer/DCR-1 
      and members of the RDE-1/AGO1 family of proteins, which are better known for 
      their roles in RNA interference (RNAi). However, stRNA function appears unrelated 
      to RNAi. Both sequence and temporal regulation of let-7 stRNA is conserved in 
      other animal species suggesting that this is an evolutionarily ancient gene. 
      Indeed, C. elegans, Drosophila and humans encode at least 86 other RNAs with 
      similar structural features to lin-4 and let-7. We postulate that other small 
      non-coding RNAs may function as stRNAs to control temporal identity during 
      development in C. elegans and other organisms.
CI  - Copyright 2002 Wiley Periodicals, Inc.
FAU - Banerjee, Diya
AU  - Banerjee D
AD  - Department of Molecular, Cellular and Development Biology, Yale University, 266 
      Whitney Ave., New Haven, CT 06520, USA.
FAU - Slack, Frank
AU  - Slack F
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Bioessays
JT  - BioEssays : news and reviews in molecular, cellular and developmental biology
JID - 8510851
RN  - 0 (3' Untranslated Regions)
RN  - 0 (Caenorhabditis elegans Proteins)
RN  - 0 (Helminth Proteins)
RN  - 0 (MicroRNAs)
RN  - 0 (RNA, Small Nuclear)
RN  - 0 (Repressor Proteins)
RN  - 0 (lin-4 microRNA, C elegans)
RN  - EC 3.1.- (Endoribonucleases)
RN  - EC 3.1.26.3 (Ribonuclease III)
SB  - IM
MH  - 3' Untranslated Regions/*genetics
MH  - Animals
MH  - Base Sequence
MH  - Caenorhabditis elegans/*genetics/physiology
MH  - Caenorhabditis elegans Proteins/genetics/metabolism
MH  - Cell Lineage
MH  - Endoribonucleases/genetics
MH  - *Gene Expression Regulation, Developmental
MH  - Gene Silencing/physiology
MH  - Helminth Proteins/genetics/metabolism
MH  - Humans
MH  - MicroRNAs
MH  - Molecular Sequence Data
MH  - Nucleic Acid Conformation
MH  - RNA, Small Nuclear/genetics/*metabolism
MH  - Repressor Proteins/genetics/metabolism
MH  - Ribonuclease III
RF  - 61
EDAT- 2002/02/09 10:00
MHDA- 2002/07/02 10:01
CRDT- 2002/02/09 10:00
PHST- 2002/02/09 10:00 [pubmed]
PHST- 2002/07/02 10:01 [medline]
PHST- 2002/02/09 10:00 [entrez]
AID - 10.1002/bies.10046 [pii]
AID - 10.1002/bies.10046 [doi]
PST - ppublish
SO  - Bioessays. 2002 Feb;24(2):119-29. doi: 10.1002/bies.10046.