PMID- 11835523
OWN - NLM
STAT- MEDLINE
DCOM- 20020402
LR  - 20191114
IS  - 0887-8013 (Print)
IS  - 1098-2825 (Electronic)
IS  - 0887-8013 (Linking)
VI  - 16
IP  - 1
DP  - 2002
TI  - Urinary levels of monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 
      (IL-8), and renal injuries in patients with type 2 diabetic nephropathy.
PG  - 1-4
AB  - We examined the correlation among the levels of urinary monocyte chemoattractant 
      protein-1 (MCP-1) and interleukin-8 (IL-8), hyperglycemia, and renal injuries in 
      patients with type 2 diabetic nephropathy. The levels of urinary MCP-1, IL-8, 
      protein excretion, blood urea nitrogen (BUN), serum creatinine (s-Cr), 
      glycohemoglobin A1c (HbA1c), and fasting plasma glucose (FPG) were measured in 24 
      patients with type 2 diabetic nephropathy and 14 healthy adults as controls. 
      Diabetic nephropathy was classified into three stages: stage 1 = 
      normoalbuminuric, stage 2 = microalbuminuric, and stage 3 = macroalbuminuric. All 
      of the patients showed normal ranges in renal function tests. Levels of urinary 
      MCP-1 in all patients with diabetic nephropathy were significantly higher than 
      those in healthy adults (P < 0.05). The levels of urinary MCP-1 in patients with 
      diabetic nephropathy increased gradually according to the clinical stage of this 
      disease. In contrast, the levels of urinary IL-8 in patients with diabetic 
      nephropathy increased in stages 2 and 3. There was a significant correlation 
      between the levels of urinary IL-8 and those of HbA1c. High glucose may stimulate 
      MCP-1 and/or IL-8 production and their excretion into the urine independently of 
      the phases or pathological lesions of this disease. It appears that IL-8 
      increased in the early stage of diabetic nephropathy, and MCP-1 increased in the 
      advanced stage of this disease. It was concluded that measurement of urinary 
      MCP-1 and IL-8 may be useful for evaluating the degree of renal injuries in 
      patients with type 2 diabetic nephropathy.
CI  - Copyright 2002 Wiley-Liss, Inc.
FAU - Tashiro, Kyouichi
AU  - Tashiro K
AD  - Division of Nephrology, Department of Internal Medicine, Juntendo University 
      School of Medicine, Tokyo, Japan.
FAU - Koyanagi, Ichiro
AU  - Koyanagi I
FAU - Saitoh, Akemi
AU  - Saitoh A
FAU - Shimizu, Ayumi
AU  - Shimizu A
FAU - Shike, Toshihide
AU  - Shike T
FAU - Ishiguro, Chizuru
AU  - Ishiguro C
FAU - Koizumi, Michiko
AU  - Koizumi M
FAU - Funabiki, Kazuhiko
AU  - Funabiki K
FAU - Horikoshi, Satoshi
AU  - Horikoshi S
FAU - Shirato, Isao
AU  - Shirato I
FAU - Tomino, Yasuhiko
AU  - Tomino Y
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Lab Anal
JT  - Journal of clinical laboratory analysis
JID - 8801384
RN  - 0 (Blood Glucose)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-8)
SB  - IM
MH  - Analysis of Variance
MH  - Blood Glucose
MH  - Case-Control Studies
MH  - Chemokine CCL2/*urine
MH  - Diabetic Nephropathies/*urine
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Humans
MH  - Interleukin-8/*urine
PMC - PMC6807737
EDAT- 2002/02/09 10:00
MHDA- 2002/04/03 10:01
PMCR- 2002/01/08
CRDT- 2002/02/09 10:00
PHST- 2002/02/09 10:00 [pubmed]
PHST- 2002/04/03 10:01 [medline]
PHST- 2002/02/09 10:00 [entrez]
PHST- 2002/01/08 00:00 [pmc-release]
AID - 10.1002/jcla.2057 [pii]
AID - JCLA2057 [pii]
AID - 10.1002/jcla.2057 [doi]
PST - ppublish
SO  - J Clin Lab Anal. 2002;16(1):1-4. doi: 10.1002/jcla.2057.