PMID- 11836119
OWN - NLM
STAT- MEDLINE
DCOM- 20020911
LR  - 20190901
IS  - 0968-0896 (Print)
IS  - 0968-0896 (Linking)
VI  - 10
IP  - 4
DP  - 2002 Apr
TI  - Synthesis and capillary electrophoretic analysis of enantiomerically enriched 
      reference standards of MDMA and its main metabolites.
PG  - 1085-92
AB  - Enantiomerically-enriched (S)-3,4-methylenedioxymethamphetamine (MDMA) and its 
      main metabolites (S)-4-hydroxy-3-methoxymethamphetamine (HMMA) and 
      (S)-3,4-dihydroxymethamphetamine (HHMA) were prepared for unequivocal 
      identification of the differential enantioselective metabolism of these compounds 
      as well as for its application in the analysis of biological samples. Capillary 
      electrophoresis with cyclodextrin derivatives and a chemical correlation of 
      (S)-MDMA, (S)-HMMA and (S)-HHMA has been performed to assign the absolute 
      stereochemistry of major isomers in analytical standards enriched with such 
      enantiomers.
FAU - Pizarro, Nieves
AU  - Pizarro N
AD  - Pharmacology Research Unit, Institut Municipal d'Investigacio Medica, Doctor 
      Aiguader 80, E-08003, Barcelona, Spain.
FAU - de la Torre, Rafael
AU  - de la Torre R
FAU - Farre, Magi
AU  - Farre M
FAU - Segura, Jordi
AU  - Segura J
FAU - Llebaria, Amadeu
AU  - Llebaria A
FAU - Joglar, Jesus
AU  - Joglar J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Bioorg Med Chem
JT  - Bioorganic & medicinal chemistry
JID - 9413298
RN  - 0 (Hallucinogens)
RN  - 0 (Lactates)
RN  - 15398-87-5 (alpha-methylepinine)
RN  - 515-30-0 (atrolactic acid)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - R7339QLN1C (Deoxyepinephrine)
SB  - IM
MH  - Deoxyepinephrine/*analogs & derivatives/analysis/metabolism/standards
MH  - Electrophoresis, Capillary
MH  - Hallucinogens/*analysis/metabolism/standards
MH  - Lactates/analysis/metabolism/standards
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*analysis/metabolism/standards
MH  - Reference Standards
MH  - Stereoisomerism
EDAT- 2002/02/12 10:00
MHDA- 2002/09/12 10:01
CRDT- 2002/02/12 10:00
PHST- 2002/02/12 10:00 [pubmed]
PHST- 2002/09/12 10:01 [medline]
PHST- 2002/02/12 10:00 [entrez]
AID - S0968089601003674 [pii]
AID - 10.1016/s0968-0896(01)00367-4 [doi]
PST - ppublish
SO  - Bioorg Med Chem. 2002 Apr;10(4):1085-92. doi: 10.1016/s0968-0896(01)00367-4.