PMID- 11836488
OWN - NLM
STAT- MEDLINE
DCOM- 20020320
LR  - 20190916
IS  - 0894-7317 (Print)
IS  - 0894-7317 (Linking)
VI  - 15
IP  - 2
DP  - 2002 Feb
TI  - Right ventricular dP/dt/P(max), not dP/dt(max), noninvasively derived from 
      tricuspid regurgitation velocity is a useful index of right ventricular 
      contractility.
PG  - 136-42
AB  - BACKGROUND: Although right ventricular (RV) contractility is important in 
      determining functional capacity, few quantification methods are clinically 
      available. RV dP/dt(max) can be assessed by Doppler echocardiography by using 
      tricuspid regurgitation (TR) but is not routinely used because of its dependency 
      on a Doppler incident angle and preload. Doppler-derived dP/dt/P(max) is 
      relatively insensitive to preload and theoretically independent of the incident 
      angle. We investigated the clinical feasibility of this index as an RV 
      contractility index. METHODS: We computed RV dP/dt(max) and dP/dt/P(max) from the 
      TR-derived RV pressure in 68 patients with dominant RV failure (13 in New York 
      Heart Association [NYHA] class I, 33 in class II, 17 in class III, and 5 in class 
      IV). Peak oxygen consumption (peak VO(2)) was measured in 20 patients during a 
      maximal bicycle ergometer test. RESULTS: dP/dt(max) did not significantly 
      correlate with NYHA class. In contrast, dP/dt/P(max) decreased monotonically with 
      the functional class (r = -0.49, P <.0001), and correlated with peak VO(2) (r = 
      0.66, P <.002). CONCLUSION: TR-derived dP/dt/P(max), not dP/dt(max), is a 
      clinically useful index of RV contractility, allowing researchers to account for 
      the functional capacity.
FAU - Kanzaki, Hideaki
AU  - Kanzaki H
AD  - Department of Cardiology, Research Institute, National Cardiovascular Center, 
      5-7-1 Fujishiro-dai, Suita, Osaka 565-8565, Japan.
FAU - Nakatani, Satoshi
AU  - Nakatani S
FAU - Kawada, Toru
AU  - Kawada T
FAU - Yamagishi, Masakazu
AU  - Yamagishi M
FAU - Sunagawa, Kenji
AU  - Sunagawa K
FAU - Miyatake, Kunio
AU  - Miyatake K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Soc Echocardiogr
JT  - Journal of the American Society of Echocardiography : official publication of the 
      American Society of Echocardiography
JID - 8801388
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Blood Flow Velocity
MH  - Echocardiography, Doppler
MH  - Feasibility Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Contraction/*physiology
MH  - Oxygen/metabolism
MH  - Pressure
MH  - Tricuspid Valve Insufficiency/diagnostic imaging/*physiopathology
MH  - Ventricular Function, Right/*physiology
EDAT- 2002/02/12 10:00
MHDA- 2002/03/21 10:01
CRDT- 2002/02/12 10:00
PHST- 2002/02/12 10:00 [pubmed]
PHST- 2002/03/21 10:01 [medline]
PHST- 2002/02/12 10:00 [entrez]
AID - S0894731702560326 [pii]
AID - 10.1067/mje.2002.115773 [doi]
PST - ppublish
SO  - J Am Soc Echocardiogr. 2002 Feb;15(2):136-42. doi: 10.1067/mje.2002.115773.