PMID- 11836659
OWN - NLM
STAT- MEDLINE
DCOM- 20020503
LR  - 20191025
IS  - 0049-0172 (Print)
IS  - 0049-0172 (Linking)
VI  - 31
IP  - 4
DP  - 2002 Feb
TI  - Clinical features and predictive factors in psoriatic arthritis-related uveitis.
PG  - 264-70
AB  - OBJECTIVES: To analyze the clinical features of uveitis in psoriatic arthritis 
      (PsA) and to investigate the factors predicting its appearance. PATIENTS AND 
      METHODS: Retrospective cohort study (1991-2000) of 71 patients diagnosed with PsA 
      according to the criteria of Moll and Wright. All patients were studied according 
      to a standard protocol. The group was divided into 3 articular categories: axial, 
      oligoarticular, and polyarticular. Human leukocyte antigen (HLA)-Cw typing was 
      performed by the polymerase chain reaction-sequence specific oligonucleotide 
      probes (PCR-SSOP) method in 65 patients and in 177 healthy donors. HLA-DR typing 
      was done by serologic methods in the 71 patients and in 82 healthy donors from 
      the same racial and geographic origin. The HLA-B27 allele also was tested among 
      the study population. All subjects with possible inflammatory ocular disease 
      received a complete ophthalmologic examination at the Ophthalmology Department of 
      our hospital. Only patients with uveitis were analyzed. Univariate and 
      multivariate analyses were applied. RESULTS: Thirteen patients had uveitis (18% 
      of this series), 4 (31%) had an insidious onset, and the remaining had 
      acute-onset uveitis. Five cases (39%) had bilateral-simultaneous uveitis. Ten 
      (77%) presented with anterior uveitis only, 2 with anterior and posterior pole 
      involvement, and only 1 case with isolated posterior pole involvement. Four 
      patients needed oral corticosteroids; 2 of them also used immunosuppresive drugs. 
      None of our patients developed sequelae or complications. In univariate analysis, 
      uveitis was associated with inflammatory back pain (P =.02), sacroiliac pain (P 
      =.001), syndesmophytes (P =.001), bilateral sacroileitis (P =.0001), HLA-DR13 (P 
      =.002), and HLA-B27 (P =.026). In multivariate analysis, the predictive factors 
      for uveitis were bilateral sacroileitis (OR 17, 95% CI: 3.7-76, P =.0002), 
      HLA-DR13 (OR 24, 95% CI: 3.78-150, P =.0056), and syndesmophytes (OR 9.7, 95% CI: 
      0.97-97, P =.05). CONCLUSIONS: Insidious onset, bilaterality, posterior pole 
      involvement, and chronicity are common in PsA patients with uveitis. In this 
      study, extensive axial involvement (bilateral sacroileitis and syndesmophytes), 
      and the HLA-DR13 antigen were the best predictors for the appearance of uveitis.
CI  - Copyright 2002, Elsevier Science (USA). All rights reserved.
FAU - Queiro, Ruben
AU  - Queiro R
AD  - Rheumatology Service and Ophthalmology Service, Complejo Hospitalario Donostia 
      (CHDO), San Sebastian-Guipuzcoa, Basque Country-Spain. ruquei@mixmail.com
FAU - Torre, Juan C
AU  - Torre JC
FAU - Belzunegui, Joaquin
AU  - Belzunegui J
FAU - Gonzalez, Carlos
AU  - Gonzalez C
FAU - De Dios, Juan R
AU  - De Dios JR
FAU - Unanue, Francisco
AU  - Unanue F
FAU - Figueroa, Manuel
AU  - Figueroa M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Semin Arthritis Rheum
JT  - Seminars in arthritis and rheumatism
JID - 1306053
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DR Serological Subtypes)
RN  - 0 (HLA-DR13 antigen)
SB  - IM
MH  - Arthritis, Psoriatic/*complications
MH  - Cohort Studies
MH  - Disease Progression
MH  - Female
MH  - HLA-DR Antigens/analysis
MH  - HLA-DR Serological Subtypes
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Sacroiliac Joint
MH  - Uveitis/drug therapy/*etiology/immunology
EDAT- 2002/02/12 10:00
MHDA- 2002/05/04 10:01
CRDT- 2002/02/12 10:00
PHST- 2002/02/12 10:00 [pubmed]
PHST- 2002/05/04 10:01 [medline]
PHST- 2002/02/12 10:00 [entrez]
AID - S0049017202344172 [pii]
AID - 10.1053/sarh.2002.28798 [doi]
PST - ppublish
SO  - Semin Arthritis Rheum. 2002 Feb;31(4):264-70. doi: 10.1053/sarh.2002.28798.