PMID- 11836682
OWN - NLM
STAT- MEDLINE
DCOM- 20020405
LR  - 20061115
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 19
IP  - 1
DP  - 2002 Feb
TI  - [Homozygous deletion of p16 and p15 genes in laryngeal squamous cell carcinoma].
PG  - 30-2
AB  - OBJECTIVE: To assess the relationship of homozygous deletion status of p16 
      (MTS1/INK4a/CDKN2A), p15(MTS2/INK4b/CDKN2B) genes and laryngeal squamous cell 
      carcinoma(LSCC) progression. METHODS: DNA was extracted from fresh tumors. 
      Homozygous deletion of p16 exon 2(p16E2) in 80 cases of LSCC and p15 exon 
      2(p15E2) in 67 cases of LSCC were detected by the polymerase chain reaction 
      technique. RESULTS: The p16E2 deletion rate in 80 cases was 12.5%(10/80); the 
      p15E2 deletion rate in 67 cases was 11.94%(8/67); the p16E2 and p15E2 codeletion 
      rate in 67 cases was 5.97%(4/67). CONCLUSION: Homozygous deletion of p16E2 and 
      p15E2 is related with LSCC oncogenesis, and it may play a role to some extent in 
      LSCC malignant progression.
FAU - Li, Fucai
AU  - Li F
AD  - Department of Medical Genetics, China Medical University, Shenyang, Liaoning, 
      110001 P. R. China. Fucaili@hotmail.com
FAU - Kang, Ning
AU  - Kang N
FAU - Li, Yinghui
AU  - Li Y
FAU - He, Guang
AU  - He G
FAU - Lin, Changkun
AU  - Lin C
FAU - Sun, Xinghe
AU  - Sun X
FAU - Gao, Hongming
AU  - Gao H
FAU - Sun, Kailai
AU  - Sun K
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
RN  - 0 (CDKN2B protein, human)
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (Cyclin-Dependent Kinase Inhibitor p15)
RN  - 0 (Cyclin-Dependent Kinase Inhibitor p16)
RN  - 0 (Genetic Markers)
RN  - 0 (Transcription Factors)
RN  - 0 (Tumor Suppressor Proteins)
SB  - IM
MH  - Carcinoma, Squamous Cell/*genetics
MH  - *Cell Cycle Proteins
MH  - Cyclin-Dependent Kinase Inhibitor p15
MH  - Cyclin-Dependent Kinase Inhibitor p16/*genetics
MH  - *Gene Deletion
MH  - Genetic Markers
MH  - Genetic Predisposition to Disease
MH  - Homozygote
MH  - Humans
MH  - Introns/genetics
MH  - Laryngeal Neoplasms/*genetics
MH  - Polymerase Chain Reaction/methods
MH  - Transcription Factors/*genetics
MH  - *Tumor Suppressor Proteins
EDAT- 2002/02/12 10:00
MHDA- 2002/04/06 10:01
CRDT- 2002/02/12 10:00
PHST- 2002/02/12 10:00 [pubmed]
PHST- 2002/04/06 10:01 [medline]
PHST- 2002/02/12 10:00 [entrez]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2002 Feb;19(1):30-2.