PMID- 11839382
OWN - NLM
STAT- MEDLINE
DCOM- 20020501
LR  - 20190826
IS  - 0145-2126 (Print)
IS  - 0145-2126 (Linking)
VI  - 26
IP  - 4
DP  - 2002 Apr
TI  - Inhibiting effects on the induction of cytotoxic T lymphocytes by dendritic cells 
      pulsed with lysates from acute myeloid leukemia blasts.
PG  - 383-9
AB  - Dendritic cells (DCs) were established from 25 patients in complete remission of 
      acute myeloid leukemia (AML). In patients during hematopoietic regeneration 
      following chemotherapy the yield of DC was comparable to that of healthy donors. 
      In patients, more than 2 months after chemotherapy, significantly less DC were 
      generated. Comparison of the antigen-presenting capacity using tetanus toxoid of 
      six AML patients and six healthy volunteers did not show significant differences. 
      In six AML patients, lymphocytes stimulated with blast cell lysate pulsed DC were 
      analyzed for cytotoxic activity against autologous blast cells. 8.4-35.6% of 
      autologous blast cells were lysed by DC stimulated lymphocytes. In three of the 
      six patients maximum lysis of target cells was achieved by unpulsed DC. Thus, it 
      seems that in some patients blast cell lysates mediate inhibitory effects, which 
      may explain to some extend immune escape mechanisms in AML.
FAU - Schui, Daniela K
AU  - Schui DK
AD  - Department of Medicine III, Haematology/Oncology, Johann Wolfgang 
      Goethe-University, Theodor-Stern-Kai 7, D-60590 Frankfurt, Germany.
FAU - Singh, Lisa
AU  - Singh L
FAU - Schneider, Bernd
AU  - Schneider B
FAU - Knau, Andrea
AU  - Knau A
FAU - Hoelzer, Dieter
AU  - Hoelzer D
FAU - Weidmann, Eckhart
AU  - Weidmann E
LA  - eng
PT  - Journal Article
PL  - England
TA  - Leuk Res
JT  - Leukemia research
JID - 7706787
SB  - IM
MH  - Acute Disease
MH  - Antigen Presentation/immunology
MH  - Cell Communication/immunology
MH  - Cells, Cultured
MH  - Cytotoxicity, Immunologic/*immunology
MH  - Dendritic Cells/*immunology/pathology
MH  - Humans
MH  - Leukemia, Myeloid/*immunology/pathology
MH  - T-Lymphocytes, Cytotoxic/*immunology/pathology
MH  - Tumor Escape/*immunology
EDAT- 2002/02/13 10:00
MHDA- 2002/05/02 10:01
CRDT- 2002/02/13 10:00
PHST- 2002/02/13 10:00 [pubmed]
PHST- 2002/05/02 10:01 [medline]
PHST- 2002/02/13 10:00 [entrez]
AID - S0145212601001412 [pii]
AID - 10.1016/s0145-2126(01)00141-2 [doi]
PST - ppublish
SO  - Leuk Res. 2002 Apr;26(4):383-9. doi: 10.1016/s0145-2126(01)00141-2.