PMID- 11840079
OWN - NLM
STAT- MEDLINE
DCOM- 20020319
LR  - 20190818
IS  - 0891-3668 (Print)
IS  - 0891-3668 (Linking)
VI  - 21
IP  - 2
DP  - 2002 Feb
TI  - Human herpesvirus 6 and cytomegalovirus infections in children with human 
      immunodeficiency virus infection and cancer.
PG  - 125-32
AB  - AIM: Measure the prevalence of human herpesvirus 6 (HHV-6) and cytomegalovirus 
      (CMV) infections in children and adolescents with HIV infection and malignancy. 
      METHODS: Semiquantitative polymerase chain reaction and serology were used to 
      test for HHV-6 and CMV infections in 31 cases (HIV-infected children with 
      cancer), 56 HIV controls (HIV-infected children without cancer) and 30 cancer 
      controls (HIV-uninfected children with cancer). RESULTS: In cases, HIV controls 
      and cancer controls, HHV-6 DNA was detected in 29, 39 and 34%, respectively, and 
      CMV DNA was detected in 13, 4 and 7%, respectively. Four cases (13%) and no HIV 
      controls or cancer controls harbored HHV-6 subtype A (P = 0.014). In cases, HIV 
      controls and cancer controls, the prevalence of HHV-6 antibodies was 58, 68 and 
      93%, respectively, and the prevalence of CMV antibodies was 71, 48 and 70%, 
      respectively. HHV-6 seroprevalence was lower in cases than in cancer controls (P 
      = 0.002), even with adjustments for age and CD4 concentrations; however, HHV-6 
      infection rates (presence of HHV-6 DNA and/or HHV-6 antibodies) were similar in 
      all groups. Stratification showed that CMV infection was more common in younger 
      patients (ages < 8 years) without severe immune suppression (CD4 concentration 
      >200 cells/microl) than in HIV controls (odds ration, 10.343; 95% confidence 
      interval, 1.65, 121.57). Geometric mean titers of serum anti-CMV antibodies, but 
      not anti-HHV-6 antibodies, were higher in cases (1:71) than in HIV controls 
      (1:33) (P = 0.005). CONCLUSIONS: HHV-6 and CMV infections were common among 
      children with HIV infection and cancer. CMV seropositivity also was associated 
      with cancer in younger HIV-infected patients who did not have severe immune 
      suppression. HHV-6A was detected only in HIV-infected children with cancer.
FAU - Leach, Charles T
AU  - Leach CT
AD  - Department of Pediatrics, Division of Infectious Diseases, The University of 
      Texas Health Science Center at San Antonio, San Antonio, TX, USA.
FAU - Pollock, Brad H
AU  - Pollock BH
FAU - McClain, Kenneth L
AU  - McClain KL
FAU - Parmley, Richard T
AU  - Parmley RT
FAU - Murphy, Sharon B
AU  - Murphy SB
FAU - Jenson, Hal B
AU  - Jenson HB
LA  - eng
GR  - AI 35710/AI/NIAID NIH HHS/United States
GR  - CA 30969/CA/NCI NIH HHS/United States
GR  - CA 55507/CA/NCI NIH HHS/United States
GR  - CA 56296/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Pediatr Infect Dis J
JT  - The Pediatric infectious disease journal
JID - 8701858
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Cytomegalovirus/*genetics/pathogenicity
MH  - Cytomegalovirus Infections/*epidemiology
MH  - DNA, Viral/analysis
MH  - Female
MH  - HIV Infections/*complications
MH  - Herpesvirus 6, Human/*genetics/pathogenicity
MH  - Humans
MH  - Infant
MH  - Male
MH  - Neoplasms/*complications/*virology
MH  - Polymerase Chain Reaction
MH  - Prevalence
MH  - Roseolovirus Infections/*epidemiology
EDAT- 2002/02/13 10:00
MHDA- 2002/03/20 10:01
CRDT- 2002/02/13 10:00
PHST- 2002/02/13 10:00 [pubmed]
PHST- 2002/03/20 10:01 [medline]
PHST- 2002/02/13 10:00 [entrez]
AID - 10.1097/00006454-200202000-00008 [doi]
PST - ppublish
SO  - Pediatr Infect Dis J. 2002 Feb;21(2):125-32. doi: 
      10.1097/00006454-200202000-00008.