PMID- 11840504
OWN - NLM
STAT- MEDLINE
DCOM- 20020722
LR  - 20190906
IS  - 0148-7299 (Print)
IS  - 0148-7299 (Linking)
VI  - 114
IP  - 1
DP  - 2002 Jan 8
TI  - HLA class I distribution in Japanese patients with schizophrenia.
PG  - 42-5
AB  - Several Caucasian studies and one Japanese study have observed associations 
      between human leukocyte antigen (HLA) class I specificities, including A24 (9) 
      and A26 (10) and schizophrenia. Most of those studies were conducted in 1970s and 
      early 1980s, when the typing technique of HLA was not adequately reliable. Also, 
      an operational diagnostic system was not employed in many of the studies. The 
      present study investigated frequencies of HLA-A specificities in schizophrenia 
      patients (ICD-10 and DSM-III-R, n=98) and sex-matched healthy controls (n=392) 
      from population in the southwestern part of Japan. HLA-B and -C specificities 
      were studied in addition. Frequencies of subjects possessing A24 and A26 were not 
      different between the patients and controls (54% and 24% in the patients and 62% 
      and 24% in the controls, respectively). No significant difference was found in 
      frequencies of other class I (A, B, and C) specificities between the patients and 
      the controls. Thus, the present study provided no evidence for an association 
      between the HLA class I specificities, including A24, A26, and others, and 
      schizophrenia in the Japanese population.
CI  - Copyright 2001 Wiley-Liss, Inc.
FAU - Matsumoto, Shunji
AU  - Matsumoto S
AD  - Department of Psychiatry, Nagasaki University School of Medicine, Nagasaki, 
      Japan.
FAU - Sasaki, Tsukasa
AU  - Sasaki T
FAU - Imamura, Akira
AU  - Imamura A
FAU - Matsuo, Katsuhisa
AU  - Matsuo K
FAU - Kayashima, Tomohiko
AU  - Kayashima T
FAU - Hashida, Aoi
AU  - Hashida A
FAU - Ono, Shinji
AU  - Ono S
FAU - Tsujita, Takahiro
AU  - Tsujita T
FAU - Matsumoto, Sumitaka
AU  - Matsumoto S
FAU - Nakane, Yishibumi
AU  - Nakane Y
FAU - Tokunaga, Katsushi
AU  - Tokunaga K
FAU - Okazaki, Yuji
AU  - Okazaki Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Med Genet
JT  - American journal of medical genetics
JID - 7708900
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-A*26 antigen)
RN  - 0 (HLA-A24 Antigen)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
SB  - IM
MH  - Adult
MH  - Female
MH  - Gene Frequency
MH  - *Genes, MHC Class I/genetics
MH  - HLA-A Antigens/*genetics
MH  - HLA-A24 Antigen
MH  - HLA-B Antigens/genetics
MH  - HLA-C Antigens/genetics
MH  - Humans
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - Schizophrenia/*genetics/immunology
EDAT- 2002/02/13 10:00
MHDA- 2002/07/23 10:01
CRDT- 2002/02/13 10:00
PHST- 2002/02/13 10:00 [pubmed]
PHST- 2002/07/23 10:01 [medline]
PHST- 2002/02/13 10:00 [entrez]
AID - 10.1002/ajmg.1629 [pii]
AID - 10.1002/ajmg.1629 [doi]
PST - ppublish
SO  - Am J Med Genet. 2002 Jan 8;114(1):42-5. doi: 10.1002/ajmg.1629.