PMID- 11840829
OWN - NLM
STAT- MEDLINE
DCOM- 20020307
LR  - 20190816
IS  - 0869-2084 (Print)
IS  - 0869-2084 (Linking)
IP  - 12
DP  - 2001 Dec
TI  - [Cytokine regulation of liver inflammation and fibrosis during chronic hepatic 
      diseases].
PG  - 37-40
AB  - Serum concentrations of antiinflammatory cytokines and growth factors were 
      measured in 30 patients with chronic viral hepatitis (HCV), mainly HCV RNA, and 
      10 patients with liver cirrhosis (LC), classes B and C according to Child-Pew. 
      Serum concentrations of tumor necrosis factor-alpha (TNF alpha), 
      granulocytic-macrophagal colony-stimulating factor (GM-CSF), and 
      growth-transforming factor-1 beta (TGF1 beta) were increased in 63.86 and 80% 
      patients with HCV and LC, respectively, and differed significantly (p < 0.05) 
      from the control. The level of TNF alpha positively correlated with the 
      concentration of alanine aminotransferase (r = 0.14). A positive correlation 
      between TGF1 beta and histologic activity index was detected (r = 0.16). 
      Increased levels (p < 0.05) of IL-5, TNF alpha, and TGF1 beta were detected in LC 
      patients in comparison with the control. Patients with LC concomitant with anemia 
      had higher (though not significantly) concentrations of TNF alpha in comparison 
      with patients without anemia. Increased levels of proinflammatory cytokines and 
      growth factors in the sera of patients with HCV and LC indicate activation of 
      immunocompetent cells, including mononuclear phagocytes. These data are in line 
      with experimental findings, indicating an important role of the studied cytokines 
      in the development of hepatic inflammation, fibrosis, and cytopenic syndromes.
FAU - Mammaev, S N
AU  - Mammaev SN
FAU - Lukina, E A
AU  - Lukina EA
FAU - Shul'pekova, Iu O
AU  - Shul'pekova IuO
FAU - Levina, A A
AU  - Levina AA
FAU - Ivashkin, V T
AU  - Ivashkin VT
LA  - rus
PT  - English Abstract
PT  - Journal Article
TT  - Reguliatsiia vospaleniia i fibroza pecheni tsitokinami pri ee khronicheskikh 
      porazheniiakh.
PL  - Russia (Federation)
TA  - Klin Lab Diagn
JT  - Klinicheskaia laboratornaia diagnostika
JID - 9432021
RN  - 0 (Cytokines)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Chronic Disease
MH  - Cytokines/*blood
MH  - Female
MH  - Hepatitis, Viral, Human/blood/*immunology/*pathology
MH  - Humans
MH  - Liver Cirrhosis/blood/*immunology/*pathology
MH  - Male
MH  - Middle Aged
EDAT- 2002/02/14 10:00
MHDA- 2002/03/08 10:01
CRDT- 2002/02/14 10:00
PHST- 2002/02/14 10:00 [pubmed]
PHST- 2002/03/08 10:01 [medline]
PHST- 2002/02/14 10:00 [entrez]
PST - ppublish
SO  - Klin Lab Diagn. 2001 Dec;(12):37-40.