PMID- 11841481
OWN - NLM
STAT- MEDLINE
DCOM- 20021223
LR  - 20191105
IS  - 0960-7420 (Print)
IS  - 0960-7420 (Linking)
VI  - 29
IP  - 1
DP  - 2002 Feb
TI  - Prevalence of human leukocyte antigen (HLA) DRB1 alleles in Kuwaiti children with 
      juvenile rheumatoid arthritis.
PG  - 1-5
AB  - The prevalence of human leukocyte antigen (HLA) DR alleles has been determined in 
      69 Kuwaiti Arab children with juvenile rheumatoid arthritis (JRA) and compared to 
      that in 212 ethnically matched normal healthy controls using a PCR-sequence 
      specific primers (PCR-SSP) method. A very high incidence of DR3 was detected in 
      JRA patients compared to the controls (P < 0.0001, RR = 2.235). The high 
      incidence of HLA-DR3 in JRA patients was accounted for mainly by an excess of 
      DRB1*0307 (P < 0.05, RR = 3.072) and DRB1*0308 (P < 0.009, RR = 2.663) compared 
      to the controls. Moreover, DR3 was more prevalent when patients with ANA-positive 
      JRA were analysed separately; 73% compared to 58% for the whole JRA patient 
      group. The frequency of DR1 was also higher in the JRA group compared to controls 
      (P = 0.019, RR = 3.585). Although the incidence of some alleles was higher in the 
      control group (DR13 and DR7), none reached a statistically significant level. All 
      the patients with iridocyclitis had either a DR1 or DR3 allele, except for one 
      child. The frequency of DRB1*03 was found to be much higher in the polyarticular 
      subtype of Kuwaiti JRA cases compared to the oligoarticular subgroup and the 
      controls. Also, a non-significant increase in the frequency of the DRB1*04, *11 
      and *15 alleles was detected in the polyarticular subtype of the Kuwaiti JRA 
      cases compared to the controls.
FAU - Alsaeid, Khaled
AU  - Alsaeid K
AD  - Pediatrics Department, Faculty of Medicine, Kuwait University, PO Box 24923, 
      Safat 13110, Kuwait. khaled@hsc.kuniv.edu.kw
FAU - Haider, M Z
AU  - Haider MZ
FAU - Kamal, H
AU  - Kamal H
FAU - Srivastva, B S
AU  - Srivastva BS
FAU - Ayoub, E M
AU  - Ayoub EM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur J Immunogenet
JT  - European journal of immunogenetics : official journal of the British Society for 
      Histocompatibility and Immunogenetics
JID - 9106962
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Arabs/*genetics
MH  - Arthritis, Juvenile/*genetics
MH  - Child
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Kuwait
EDAT- 2002/02/14 10:00
MHDA- 2002/12/27 04:00
CRDT- 2002/02/14 10:00
PHST- 2002/02/14 10:00 [pubmed]
PHST- 2002/12/27 04:00 [medline]
PHST- 2002/02/14 10:00 [entrez]
AID - 253 [pii]
AID - 10.1046/j.1365-2370.2002.00253.x [doi]
PST - ppublish
SO  - Eur J Immunogenet. 2002 Feb;29(1):1-5. doi: 10.1046/j.1365-2370.2002.00253.x.