PMID- 11844145
OWN - NLM
STAT- MEDLINE
DCOM- 20020521
LR  - 20190826
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 58
IP  - 5
DP  - 2001 Nov
TI  - MCP-1 promoter polymorphism in Spanish patients with systemic lupus 
      erythematosus.
PG  - 335-8
AB  - The possible role of the functional polymorphism located in the regulatory region 
      of the monocyte chemoattractant protein-1 (MCP-1) gene in the susceptibility to 
      systemic lupus erythematosus (SLE) was investigated. Two hundred and seventy-six 
      SLE patients (among them, 99 with lupus nephritis and 55 with cutaneous 
      vasculitis) and 194 ethnically matched healthy controls were included in the 
      study. Genotyping for -2518 (A/G) MCP-1 gene polymorphism was performed by 
      polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) 
      analysis. No association between -2518 (A/G) MCP-1 polymorphism and 
      susceptibility to SLE nor to lupus nephritis was found. However, a significant 
      increase in the frequency of genotype AG and a decrease in the frequency of 
      genotype AA were found among patients with cutaneous vasculitis (51% of AG vs. 
      32% in individuals without cutaneous vasculitis; P=0.008, OR=2.2, 95% CI: 
      1.18-4.25; and 47% of AA vs. 64%; P=0.03, OR=0.5, 95% CI: 0.27-0.96, 
      respectively). These results indicate an association between the presence of G at 
      position -2518 in the MCP-1 promoter region and the presence of cutaneous 
      vasculitis among patients with SLE. This polymorphism does not seem to influence 
      the susceptibility to SLE nor the appearance of lupus nephritis. Further studies 
      are necessary in order to elucidate the role of this polymorphism in the 
      pathogenesis of other inflammatory autoimmune diseases.
FAU - Aguilar, F
AU  - Aguilar F
AD  - Servicio de Inmunologia, Hospital Universitario Virgen del Rocio, Servicio 
      Andaluz de Salud, Sevilla, Spain.
FAU - Gonzalez-Escribano, M F
AU  - Gonzalez-Escribano MF
FAU - Sanchez-Roman, J
AU  - Sanchez-Roman J
FAU - Nunez-Roldan, A
AU  - Nunez-Roldan A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Chemokine CCL2/*analysis/*genetics
MH  - Disease Susceptibility
MH  - Female
MH  - Gene Frequency
MH  - Humans
MH  - Lupus Erythematosus, Systemic/*blood/*epidemiology/*pathology
MH  - Lupus Nephritis/genetics
MH  - Male
MH  - Polymorphism, Genetic
MH  - Spain
MH  - Vasculitis, Leukocytoclastic, Cutaneous/genetics
EDAT- 2002/02/15 10:00
MHDA- 2002/05/22 10:01
CRDT- 2002/02/15 10:00
PHST- 2002/02/15 10:00 [pubmed]
PHST- 2002/05/22 10:01 [medline]
PHST- 2002/02/15 10:00 [entrez]
AID - 580508 [pii]
AID - 10.1034/j.1399-0039.2001.580508.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2001 Nov;58(5):335-8. doi: 10.1034/j.1399-0039.2001.580508.x.