PMID- 11846036
OWN - NLM
STAT- MEDLINE
DCOM- 20020305
LR  - 20191105
IS  - 1420-682X (Print)
IS  - 1420-682X (Linking)
VI  - 59
IP  - 1
DP  - 2002 Jan
TI  - The Ror receptor tyrosine kinase family.
PG  - 83-96
AB  - Receptor tyrosine kinases (RTKs) participate in numerous developmental decisions. 
      Ror RTKs are a family of orphan receptors that are related to muscle specific 
      kinase (MuSK) and Trk neurotrophin receptors. MuSK assembles acetylcholine 
      receptors at the neuromuscular junction, and Trk receptors function in the 
      developing nervous system (reviewed in [3-5]). Rors have been identified in 
      nematodes, insects and mammals. Recent studies have begun to shed light on Ror 
      function during development. In most species, Rors are expressed in many tissue 
      types during development. Analyses of mutants that are defective in the single 
      nematode Ror demonstrate a role in cell migration and in orienting cell polarity. 
      Mice lacking one of the two Ror gene products display defects in bone and heart 
      formation. Similarly, two different human bone development disorders, dominant 
      brachydactyly B and recessive Robinow syndrome, result from mutations in one of 
      the human Ror genes.
FAU - Forrester, W C
AU  - Forrester WC
AD  - Department of Biology, Indiana University, Bloomington 47405-3700, USA. 
      wforrest@bio.indiana.edu
LA  - eng
SI  - GENBANK/A47299
GR  - R01 HD37815/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - Switzerland
TA  - Cell Mol Life Sci
JT  - Cellular and molecular life sciences : CMLS
JID - 9705402
RN  - 0 (Caenorhabditis elegans Proteins)
RN  - 0 (Protein Sorting Signals)
RN  - EC 2.7.10.1 (CAM-1 protein, C elegans)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Receptor Tyrosine Kinase-like Orphan Receptors)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Caenorhabditis elegans Proteins
MH  - *Conserved Sequence
MH  - Genetic Diseases, Inborn/genetics
MH  - Humans
MH  - Molecular Sequence Data
MH  - Multigene Family
MH  - Mutation/genetics
MH  - Protein Sorting Signals
MH  - Protein Structure, Tertiary
MH  - Receptor Protein-Tyrosine Kinases/*chemistry/genetics/*metabolism
MH  - Receptor Tyrosine Kinase-like Orphan Receptors
RF  - 68
EDAT- 2002/02/16 10:00
MHDA- 2002/03/07 10:01
CRDT- 2002/02/16 10:00
PHST- 2002/02/16 10:00 [pubmed]
PHST- 2002/03/07 10:01 [medline]
PHST- 2002/02/16 10:00 [entrez]
AID - 10.1007/s00018-002-8407-9 [doi]
PST - ppublish
SO  - Cell Mol Life Sci. 2002 Jan;59(1):83-96. doi: 10.1007/s00018-002-8407-9.