PMID- 11846867
OWN - NLM
STAT- MEDLINE
DCOM- 20020312
LR  - 20191105
IS  - 0905-6157 (Print)
IS  - 0905-6157 (Linking)
VI  - 12
IP  - 6
DP  - 2001 Dec
TI  - Do early childhood immunizations influence the development of atopy and do they 
      cause allergic reactions?
PG  - 296-311
AB  - Concerns about allergic side-effects of vaccines and about a possible promotion 
      of allergic diseases contribute to incomplete vaccination rates in childhood. 
      This article reviews the current understanding of these issues. There is evidence 
      that pertussis and diphtheria/tetanus antigens elicit immunoglobulin E (IgE) 
      antibody formation as part of the immune response. In murine models, pertussis 
      toxin is an effective adjuvant for IgE formation against simultaneously 
      administered antigens. In children, however, sensitization to unrelated antigens 
      or development of allergic diseases do not seem to be augmented. In contrast, 
      bacille Calmette-Guerin (BCG) and measles vaccination have been proposed as 
      suppressors of allergy because of their T helper 1 (Th1)-fostering properties. In 
      the murine system, BCG inhibits allergic sensitization and airway 
      hyper-reactivity. Some epidemiological studies in humans suggest an inhibitory 
      effect of tuberculosis on allergy. BCG vaccination in children, however, has no 
      or merely a marginal suppressive effect on atopy. Other vaccine components such 
      as egg proteins, gelatin, and antibiotics are a potential hazard to children with 
      severe clinical reactions to these allergens. These rare children should be 
      vaccinated under special precautions. In conclusion, vaccination programs do not 
      explain the increasing prevalence of allergic diseases, but individual children 
      may uncommonly develop an allergic reaction to a vaccine. The risks of not 
      vaccinating children, however, far outweigh the risk for allergy. Therefore, 
      childhood vaccination remains an essential part of child health programs and 
      should not be withheld, even from children predisposed for allergy.
FAU - Gruber, C
AU  - Gruber C
AD  - Department of Pediatric Pneumology and Immunology, Charite - Humboldt University, 
      Berlin, Germany. christoph.grueber@charite.de
FAU - Nilsson, L
AU  - Nilsson L
FAU - Bjorksten, B
AU  - Bjorksten B
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (Antibodies, Anti-Idiotypic)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Animals
MH  - Antibodies, Anti-Idiotypic/drug effects
MH  - Chick Embryo
MH  - Child
MH  - Child, Preschool
MH  - Drug Hypersensitivity/*etiology
MH  - Humans
MH  - Hypersensitivity/*etiology
MH  - Hypersensitivity, Immediate/*chemically induced
MH  - Immunization/*adverse effects
MH  - Immunoglobulin E/drug effects
MH  - Infant
RF  - 180
EDAT- 2002/02/16 10:00
MHDA- 2002/03/13 10:01
CRDT- 2002/02/16 10:00
PHST- 2002/02/16 10:00 [pubmed]
PHST- 2002/03/13 10:01 [medline]
PHST- 2002/02/16 10:00 [entrez]
AID - 046 [pii]
AID - 10.1034/j.1399-3038.2001.1r046.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2001 Dec;12(6):296-311. doi: 
      10.1034/j.1399-3038.2001.1r046.x.